지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 587 - 595 (9page)
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초록· 키워드
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Objective The association between benzodiazepine use and the risk of cognitive impairment or dementia has been controversial. Our study aims to detect this association through a case/non-case method using the Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database (KIDS-KD) between 2007 and 2016.Methods Cases were adverse event (AE)-pairs with suspected cognitive impairment or dementia. 10 non-cases were matched to each case on age and sex. Exposure was defined as use of benzodiazepines, including long-, intermediate-, and short-acting benzodiazepine. We conducted multivariable logistic regression analyses to estimate reporting odds ratios (ROR) and 95% confidence intervals (CI).Results Of the 1,086,584 AE-pairs, 887 cases were suspected AE-pairs of cognitive impairment or dementia, and 775,444 non-cases were selected. Benzodiazepine use was associated with increased AE-pairs of cognitive impairment or dementia when assessed using those with certain, probable, and/or possible in causality assessments (ROR=2.69, 95% CI=1.66–4.38). Higher ROR estimates were shown in female (2.33, 1.48–3.67) and in those with polypharmacy (2.20, 1.35–3.57). Dementia safety profiles were inconsistent across individual benzodiazepine components.Conclusion These results suggest the potentially increased association between benzodiazepine use and cognitive impairment or dementia in female and those with polypharmacy. Inconsistent safety profiles of benzodiazepine components should be further investigated.
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참고문헌 (39)
참고문헌 신청
Anttila T / 2004 / Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age : a prospective population based study / BMJ Brit Med J 329:539
Donoghue J / 2010 / Usage of benzodiazepines : a review / Int J Psychiatry Clin 14:78~87
Gray SL / 2016 / Benzodiazepine use and risk of incident dementia or cognitive decline : prospective population based study / BMJ Brit Med J 352:i90
Billioti de Gage S / 2012 / Benzodiazepine use and risk of dementia: prospective population based study / BMJ Brit Med J 345:e6231
Billioti de Gage S / 2014 / Benzodiazepine use and risk of Alzheimer’s disease: case-control study / BMJ 349:g5205
Donoghue J / 2010 / Usage of benzodiazepines : a review / Int J Psychiatry Clin 14:78~87
Gray SL / 2016 / Benzodiazepine use and risk of incident dementia or cognitive decline : prospective population based study / BMJ Brit Med J 352:i90
Billioti de Gage S / 2012 / Benzodiazepine use and risk of dementia: prospective population based study / BMJ Brit Med J 345:e6231
Billioti de Gage S / 2014 / Benzodiazepine use and risk of Alzheimer’s disease: case-control study / BMJ 349:g5205
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