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논문 기본 정보

자료유형
학술저널
저자정보
송인애 (분당서울대학교병원 마취통증의학과) 오탁규 (분당서울대학교병원 마취통증의학과) 박혜연 (분당서울대학교병원 정신건강의학과)
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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제62권 제6호
발행연도
2021.1
수록면
528 - 534 (7page)

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Purpose: Studies have reported mixed results on the association between benzodiazepine use and mortality. Here, we investigatedwhether benzodiazepine use is associated with a higher risk of 5-year all-cause mortality, and examined the association betweenbenzodiazepine use and 5-year disease-specific mortality. Materials and Methods: In this population-based cohort study, a nationally representative sample cohort in South Korea was examined. In 2010, benzodiazepine users were defined as individuals prescribed benzodiazepine continuously over 30 days for regularadministration, and all other subjects were included in the control group. The primary endpoint was 5-year all-cause mortality,evaluated from 2011 to 2015. Propensity score (PS) matching and time-dependent Cox regression were performed for statisticalanalysis, which included benzodiazepine use during 2011?2015 as a time-dependent variable. Results: A total of 822414 adult individuals were included in the final analysis, and the all-cause 5-year mortality was recorded in20991 individuals (2.7%). The benzodiazepine group included 30837 patients and the control group comprised 791377 patients. After PS matching, 61672 individuals (30836 in each group) were included in the final analysis. After PS matching, the 5-year allcausemortality in the benzodiazepine group was 10.0% (3082/30836), whereas that in the control group was 9.4% (2893/30836). In time-dependent Cox regression analysis of the PS-matched cohort, the benzodiazepine group showed 1.15-fold higher 5-yearall-cause mortality (hazard ratio: 1.15, 95% confidence interval: 1.09?1.22; p<0.001) compared to the control group. Conclusion: Benzodiazepine use was associated with increased 5-year all-cause mortality in the South Korean adult population. Further studies are needed to confirm these findings.

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