지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 4 - 10 (7page)
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초록· 키워드
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Etifoxine (etafenoxine, StresamⓇ) is a non-benzodiazepine anxiolytic with an anticonvulsant effect. It was developed in the 1960s for anxiety disorders and is currently being studied for its ability to promote peripheral nerve healing and to treat chemotherapy-induced pain. In addition to being mediated by GABAAα2 receptors like benzodiazepines, etifoxine appears to produce anxiolytic effects directly by binding to β2 or β3 subunits of the GABAA receptor complex. It also modulates GABAA receptors indirectly via stimulation of neurosteroid production after etifoxine binds to the 18 kDa translocator protein (TSPO) of the outer mitochondrial mem-brane in the central and peripheral nervous systems, previously known as the peripheral benzodiazepine receptor (PBR). Therefore, the effects of etifoxine are not completely reversed by the benzodiazepine antagonist flumazenil. Etifoxine is used for various emotional and bodily reactions followed by anxiety. It is contraindicated in situations such as shock, severely impaired liver or kidney function, and severe respiratory failure. The average dosage is 150 mg per day for no more than 12 weeks. The most common adverse effect is drowsiness at the initial stage. It does not usually cause any withdrawal syndromes. In conclusion, etifoxine shows less adverse effects of anterograde amnesia, sedation, impaired psychomotor performance, and withdrawal syn-dromes than those of benzodiazepines. It potentiates GABAA receptor-function by a direct allosteric effect and by an indirect mechanism involving the activation of TSPO. It seems promising that non-benzodiazepine anxiolytics including etifoxine will replenish shortcomings of benzodiazepines and selective serotonin reuptake inhibitors according to animated studies related to TSPO. (Korean J Pain 2015; 28: 4-10)
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참고문헌 (25)
참고문헌 신청
Almeida TF / 2004 / Afferent pain pathways : a neuroanatomical review / Brain Res 1000 : 40 ~ 56
Aouad M / 2009 / Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alpha-reduced neur
Aouad M / 2014 / Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental
Dai T / 2014 / Etifoxine promotes glia-derived neurite outgrowth in vitro and in vivo / J Reconstr Microsurg 30 : 381 ~ 388
Daugherty DJ / 2013 / A TSPO ligand is protective in a mouse model of multiple sclerosis / EMBO Mol Med 5 : 891 ~ 903
Aouad M / 2009 / Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alpha-reduced neur
Aouad M / 2014 / Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental
Dai T / 2014 / Etifoxine promotes glia-derived neurite outgrowth in vitro and in vivo / J Reconstr Microsurg 30 : 381 ~ 388
Daugherty DJ / 2013 / A TSPO ligand is protective in a mouse model of multiple sclerosis / EMBO Mol Med 5 : 891 ~ 903
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