지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제21권 제2호
- 발행연도
- 2022.4
- 수록면
- 71 - 78 (8page)
- DOI
- 10.12779/dnd.2022.21.2.71
이용수
초록· 키워드
오류제보하기
Background and Purpose: The expression of the 18-kDA mitochondrial translocator protein (TSPO) in the brain is an attractive target to study neuroinflammation. However, the binding properties of TSPO ligands are reportedly dependent on genetic polymorphism of the TSPO gene (rs6971). The objective of this study is to investigate the rs6971 gene polymorphism in the Korean population.
Methods: We performed genetic testing on 109 subjects including patients with mild cognitive impairment, Alzheimer’s disease (AD) dementia, non-AD dementia, and cognitively unimpaired participants. Magnetic resonance imaging scans and detailed neuropsychological tests were also performed, and 29 participants underwent 18F-DPA714 PET scans. Exon 4 of the TSPO gene containing the polymorphism rs6971 (Ala or Thr at position 147) was polymerase chain reaction amplified and sequenced using the Sanger method. The identified rs6971 genotype codes (C/C, C/T, or T/T) of the TSPO protein generated high-, mixed-, or low-affinity binding phenotypes (HABs, MABs, and LABs), respectively.
Results: We found that 96.3% of the study subjects were HAB (105 out of 109 subjects), and 3.7% of the subjects were MAB (4 out of 109 subjects). 18F-DPA-714 PET scans showed nonspecific binding to the thalamus and brainstem, and increased tracer uptake throughout the cortex in cognitively impaired patients. The participant with the MAB polymorphism had a higher DPA714 signal throughout the cortex.
Conclusions: The majority of Koreans are HAB (aprox. 96%). Therefore, the polymorphism of the rs6971 gene would have a smaller impact on the availability of second-generation TSPO PET tracers.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A novel tricyclic derivative for PET imaging of the translocator protein
대한방사성의약품학회지
2016 .01
-
Evaluation of the TSPO radioligand [18F]CB251 in a rat model of autoimmune myocarditis
한국실험동물학회 학술발표대회 논문집
2016 .08
-
A pyrazolopyrimidine-based radioligand for imaging of the translocator protein
대한방사성의약품학회지
2016 .01
-
A novel quinoline derivative with high affinity for the translocator protein
대한방사성의약품학회지
2015 .01
-
Synthesis and biological evaluation of tricarbonyl technetium labeled 2-(4-chloro)phenyl-imidazo[1,2-a]pyridine analog (<sup>99m</sup>Tc-CB257) as a TSPO-binding ligand
대한방사성의약품학회지
2018 .01
-
In Vivo Fluorescence Imaging of Glioblastoma using Translocator Proteins (TSPOs) Targeted Nanoparticles
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Semi-Automated image analysis technique for quantifying cellular expression of mitochondrial translocator protein (TSPO) targeting nanoparticles using free open-source software
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Visualization of interscapular brown adipose tissue (iBAT) with TSPO targeting ligand by Cerenkov luminescence imaging (CLI) in the UCP1 Thermomouse
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population
Korean Circulation Journal
2016 .01
-
Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Association Study between Norepinephrine Transporter Gene Polymorphism and Schizophrenia in a Korean Population
PSYCHIATRY INVESTIGATION
2015 .01
-
Association of the Serotonin 2A Receptor rs6311 Polymorphism with Diurnal Preference in Koreans
PSYCHIATRY INVESTIGATION
2020 .01
-
IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis
Yonsei Medical Journal
2015 .01
-
Role of IL-18 Gene Promoter Polymorphisms, Serum IL-18 Levels, and Risk of Hepatitis B Virus-related Liver Disease in the Guangxi Zhuang Population: a Retrospective Case-Control Study
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Association of the Single-Nucleotide Polymorphism and Haplotype of the Complement Receptor 1 Gene with Malaria
Yonsei Medical Journal
2015 .01
-
Analysis of Association between Norepinephrine Transporter Gene Polymorphisms and Personality Traits of NEO-FFI in a Japanese Population
PSYCHIATRY INVESTIGATION
2015 .01
-
Significance of ATM Gene Polymorphisms in Chronic Myeloid Leukemia - a Case Control Study from India
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
면역체계 이상 활성화를 유도할 수 있는 보체계 유전자 다형성 고찰
Clinical Transplantation and Research
2016 .01
-
Genetic Associations of Mitochondrial DNA Polymorphisms with Behçet’s Disease in a Korean Population: A Pilot Study
대한류마티스학회지
2016 .01
-
Lack of Association between the MiR146a Polymorphism and Susceptibility to Thai Childhood Acute Lymphoblastic Leukemia
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0