Single Nucleotide Polymorphisms in the Gc Gene for Vitamin D Binding Protein in Common Cancers in Thailand

Maneechay, Wanwisa; Boonpipattanapong, Teeranut; Kanngurn, Samornmas; Puttawibul, Puttisak; Geater, Sarayut Lucien; Sangkhathat, Surasak

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자료유형: 학술저널

저자정보: Maneechay, Wanwisa (Central Research Laboratory, Prince of Songkla University) Boonpipattanapong, Teeranut (Department of Surgery, Faculty of Medicine, Prince of Songkla University) Kanngurn, Samornmas (Surgical Pathology, Bumrungrad International Hospital) Puttawibul, Puttisak (Department of Surgery, Faculty of Medicine, Prince of Songkla University) Geater, Sarayut Lucien (Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University) Sangkhathat, Surasak (Department of Surgery, Faculty of Medicine, Prince of Songkla University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제8호

발행연도: 2015.1

수록면: 3,339 - 3,344 (6page)

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Background: This case-control study aimed to determine if there were any associations between the two single nucleotide polymorphisms (SNPs) in Gc, rs7041 (Asp416Glu) and rs4588 (Thr420Lys) and 3 common cancers (breast, lung and colorectal) in Thai patients. Materials and Methods: Two hundred and eighty two colorectal, 101 breast and 113 lung cancer patients were recruited from one institute during 2011-2013. The controls were age-matched volunteers who had a negative history of index cancers. In addition, vitamin D levels were compared among different genotypes in the 2 SNPs. Results: The minor allele frequencies of rs7041 (G) and rs4588 (A) were 0.32 and 0.24, respectively. Under the dominant model, the study found significant associations between minor-allele genotypes of the SNP rs7041 (TG/GG) and lung cancer (odds ratio [OR] 1.78, 95% CI 1.05-3.03). When subgroup analysis was performed according to sex and age at diagnosis, the study found that the minor-allele genotypes of rs7041 (TG/GG) were significantly associated with colorectal cancer in patients whose age at diagnosis was more than 60 years (OR 1.67, 95%CI 1.06-2.61) and the minor-allele genotypes of rs4588 (CA/AA) were significantly associated with colorectal cancer in males aged 60 years or less (OR 2.34, 95%CI 1.25-4.37). When SNP combinations (rs7041-rs4588) were examined, the TT-CA combination had a significant protective association with lung cancer (OR 0.44, 95% CI 0.22-0.85). On evaluation of serum 25(OH)D levels in 205 individuals without cancer (males 144, females 61), the proportion of subjects with low serum vitamin D (< 20 ng/ml) in those harboring CA or AA genotypes of rs4588 (41.7%) was significantly higher than the CC genotype (15.5%, p-value < 0.01). Conclusions: Genetic polymorphisms in Gc were associated with lung and colorectal cancers in Thai patients. Lower serum 25(OH)D in minor variants of rs4588 may explain this association.

#Vitamin D #Vitamin D binding protein #colorectal cancer #lung cancer #Gc polymorphisms

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