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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제1호
- 발행연도
- 2020.1
- 수록면
- 47 - 52 (6page)
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초록· 키워드
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We previously demonstrated that Bordetella bronchiseptica (B. bronchiseptica) antigen (Ag) enhances the Mycoplasma hyopneumoniae Ag-specific immune response. The focus of this study was whether acellular bacterin of B. bronchiseptica could be used as an adjuvant to increase antigen-presenting capability of dendritic cells (DCs) by increasing the level of activation. The metabolic activity of DCs was increased by B. bronchiseptica, similar to lipopolysaccharide (LPS). Flow cytometry analysis revealed that B. bronchiseptica increases the expression of major histocompatibility complex class-2, cluster of differentiation (CD)40, CD54, and CD86 which are closely related to DC-mediated immune responses. B. bronchiseptica enhanced the production of cytokines related to adaptive immune responses. Furthermore, the survival rate of B. bronchiseptica-injected groups was 100% at 15 and 20 mg/kg doses, whereas that of LPS-injected groups was only 20%, 0% at 15 and 20 mg/kg doses respectively, and so B. bronchiseptica is likely to be safer than LPS. Taken together, these results indicate that B. bronchiseptica can be used as an adjuvant to enhance the antigen-presenting capability of DCs. B. bronchiseptica is a candidate for producing vaccines, especially in case of DC-mediating efficacy and safety demands. This study provides researchers and clinicians with valuable information regarding the usage of B. bronchiseptica as a safe bacteria-derived immunostimulating agent for developing efficient vaccines.
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참고문헌 (20)
참고문헌 신청
Karch CP / 2016 / Vaccine technologies : from whole organisms to rationally designed protein assemblies / Biochem Pharmacol 120:1~14
Marciani DJ / 2003 / Vaccine adjuvants : role and mechanisms of action in vaccine immunogenicity / Drug Discov Today 8:934~943
Del Giudice G / 2018 / Correlates of adjuvanticity : a review on adjuvants in licensed vaccines / Semin Immunol 39:14~21
Coffman RL / 2010 / Vaccine adjuvants : putting innate immunity to work / Immunity 33:492~503
Dunne A / 2015 / A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine / Mucosal Immunol 8:607~617
Marciani DJ / 2003 / Vaccine adjuvants : role and mechanisms of action in vaccine immunogenicity / Drug Discov Today 8:934~943
Del Giudice G / 2018 / Correlates of adjuvanticity : a review on adjuvants in licensed vaccines / Semin Immunol 39:14~21
Coffman RL / 2010 / Vaccine adjuvants : putting innate immunity to work / Immunity 33:492~503
Dunne A / 2015 / A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine / Mucosal Immunol 8:607~617
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