지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.2
- 수록면
- 33 - 43 (11page)
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초록· 키워드
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Cell-penetrating peptides (CPPs) are short amino acids that have been widely used to deliver macromolecules such as proteins, peptides, DNA, or RNA, to control cellular behavior for therapeutic purposes. CPPs have been used to treat immunological diseases through the delivery of immune modulatory molecules in vivo. Their intracellular delivery efficiency is highly synergistic with the cellular characteristics of the dendritic cells (DCs), which actively uptake foreign antigens. DC-based vaccines are primarily generated by pulsing DCs ex vivo with various immunomodulatory antigens. CPP conjugation to antigens would increase DC uptake as well as antigen processing and presentation on both MHC class II and MHC class I molecules, leading to antigen specific CD4⁺ and CD8⁺ T cell responses. CPP-antigen based DC vaccination is considered a promising tool for cancer immunotherapy due to the enhanced CTL response. In this review, we discuss the various applications of CPPs in immune modulation and DC vaccination, and highlight the advantages and limitations of the current CPP-based DC vaccination.
목차
INTRODUCTION
CPP APPLICATIONS IN IMMUNE MODULATION
DC VACCINATION WITH CELL-PENETRATING PEPTIDES
CONCLUSION
REFERENCES
참고문헌 (109)
참고문헌 신청
Erazo-Oliveras, A., N. Muthukrishnan, R. Baker, T. Y. Wang, and J. P. Pellois. 2012. Improving the endosomal escape of cellpenetrating peptides and their cargos: strategies and challenges. Pharmaceuticals (Basel) 5: 1177-1209.
Ramsey, J. D., and N. H. Flynn. 2015. Cell-penetrating peptides transport therapeutics into cells. Pharmacol. Ther. 154: 78-86.
Bechara, C., and S. Sagan. 2013. Cell-penetrating peptides: 20 years later, where do we stand? FEBS Lett. 587: 1693-1702.
Ryser, H. J. and R. Hancock. 1965. Histones and basic polyamino acids stimulate the uptake of albumin by tumor cells in culture. Science 150: 501-503.
Shen, W. C., and H. J. Ryser. 1978. Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins. Proc. Natl. Acad. Sci. U. S. A. 75: 1872-1876.
Ramsey, J. D., and N. H. Flynn. 2015. Cell-penetrating peptides transport therapeutics into cells. Pharmacol. Ther. 154: 78-86.
Bechara, C., and S. Sagan. 2013. Cell-penetrating peptides: 20 years later, where do we stand? FEBS Lett. 587: 1693-1702.
Ryser, H. J. and R. Hancock. 1965. Histones and basic polyamino acids stimulate the uptake of albumin by tumor cells in culture. Science 150: 501-503.
Shen, W. C., and H. J. Ryser. 1978. Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins. Proc. Natl. Acad. Sci. U. S. A. 75: 1872-1876.
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