지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제48권 제1호
- 발행연도
- 2018.1
- 수록면
- 77 - 87 (11page)
- DOI
- 10.1007/s40005-017-0373-1
이용수
초록· 키워드
오류제보하기
Cell-penetrating peptides (CPPs) have been receiving much attention over the last few decades due to their unique ability to translocate across plasma membranes efficiently and carry the wide range of macromolecular cargoes with them. Although their intracellular delivery mechanism has not been fully elucidated, CPP-based cellular uptake, mainly mediated by direct transduction or endocytosis, depends on structural characteristics of CPPs, the type and concentration of CPPs or cargoes, and cell types being treated. To overcome the intrinsic drawbacks of CPPs including lack of cell or tissue specificity, short plasma half-life, and endosomal sequestration, various strategies have been suggested such as activatable CPPs (ACPPs), introduction of targeting moieties and fusion peptides, and topical delivery systems for clinical application. In this review, we provide an overview of up-to-date knowledge of intracellular delivery mechanisms of CPPs and introduce potential topical applications of CPPs such as transdermal, nasal and ocular delivery for non-invasive delivering the therapeutic proteins or peptides.
목차
등록된 정보가 없습니다.
참고문헌 (113)
참고문헌 신청
Agrawa P / 2016 / CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides / Nucleic Acids Res 44(D1):D1098~D1103
Aguilera TA / 2009 / Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides / Integr Biol 1(5-6):371~381
Akita H / 2011 / Improving in vivo hepatic transfection activity by controlling intracellular trafficking: the function of GALA and maltotriose / Mol Pharm 8(4):1436~1442
Amand HL / 2012 / Cell surface binding and uptake of arginine-and lysine-rich penetratin peptides in absence and presence of proteoglycans / Biochim Biophys Acta 1818(11):2669~2678
Auger I / 1993 / Computational techniques to predict amphipathic helical segments;The amphipathic helix / CRC Press :7~19
Aguilera TA / 2009 / Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides / Integr Biol 1(5-6):371~381
Akita H / 2011 / Improving in vivo hepatic transfection activity by controlling intracellular trafficking: the function of GALA and maltotriose / Mol Pharm 8(4):1436~1442
Amand HL / 2012 / Cell surface binding and uptake of arginine-and lysine-rich penetratin peptides in absence and presence of proteoglycans / Biochim Biophys Acta 1818(11):2669~2678
Auger I / 1993 / Computational techniques to predict amphipathic helical segments;The amphipathic helix / CRC Press :7~19
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Cell penetrating peptides as an innovative approach for drug delivery; then, present and the future
Journal of Pharmaceutical Investigation
2016 .06
-
Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination
Immune Network
2016 .02
-
Novel Cell Permeable Peptide Based on Multi Basic Furin-dependent Cleavage Site of Respiratory Syncytial Virus Fusion Protein
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2018 .06
-
Cell-Penetrating Peptide(CPP) potential as a treatment for colorectal cancer with peritoneal metastasis
대한외과학회 학술대회 초록집
2019 .10
-
Prevalence of idiopathic scoliosis in girls with central precocious puberty: effect of a gonadotropin-releasing hormone agonist
Annals of Pediatirc Endocrinology & Metabolism
2020 .01
-
Pathological brain lesions in girls with central precocious puberty at initial diagnosis in Southern Vietnam
Annals of Pediatirc Endocrinology & Metabolism
2022 .06
-
일측성 성대마비 환자 평가에서 Cepstral Peak Prominence의 유용성
대한후두음성언어의학회지
2017 .01
-
Genetic Variations of the KISS1R Gene in Korean Girls with Central Precocious Puberty
Journal of Korean Medical Science
2017 .01
-
Etiological trends in male central precocious puberty
Annals of Pediatirc Endocrinology & Metabolism
2018 .01
-
Effect of Cell Pentrating Peptide(CPP)-Oxaliplatin Conjugate on The Treatment of Colorectal Cancer
대한외과학회 학술대회 초록집
2020 .11
-
The Diagnostic Value of Pelvic Ultrasound in Girls with Central Precocious Puberty
전남의대학술지
2016 .01
-
Gabapentin for the Treatment of Chronic Pelvic Pain Syndrome in Patients with High Pain Score
Urogenital Tract Infection
2019 .01
-
The Effect of α-Blockers Monotherapy vs. Combination Antibiotic Therapy on Symptom Alleviation in Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Urogenital Tract Infection
2018 .01
-
Proposed New Pathophysiology of Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Urogenital Tract Infection
2015 .01
-
Peptides as drug delivery vehicles across biological barriers
Journal of Pharmaceutical Investigation
2018 .01
-
Evaluation of cephalometric characteristics and skeletal maturation of the cervical vertebrae and hand-wrist in girls with central precocious puberty
대한치과교정학회지
2020 .05
-
Chronic Prostatitis/Chronic Pelvic Pain Syndrome and Male Bladder Pain Syndrome/Interstitial Cystitis: How Are They Related?
Urogenital Tract Infection
2017 .01
-
Designing a drug delivery system for improved tumor treatment and targeting by functionalization of a cell-penetrating peptide
Journal of Pharmaceutical Investigation
2019 .01
-
일측성 성대마비 환자 평가에서 CPP의 유용성
대한음성언어의학회 학술대회
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0