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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제1호
- 발행연도
- 2020.1
- 수록면
- 39 - 46 (8page)
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Alzheimer’s disease (AD) is the most common neurodegenerative disorder causing dementia worldwide, and is mainly characterized by aggregated β-amyloid (Aβ). Increasing evidence has shown that plant extracts have the potential to delay AD development. The plant sterol β-Sitosterol has a potential role in inhibiting the production of platelet Aβ, suggesting that it may be useful for AD prevention. In the present study, we aimed to investigate the effect and mechanism of β-Sitosterol on deficits in learning and memory in amyloid protein precursor/presenilin 1 (APP/PS1) double transgenic mice. APP/PS1 mice were treated with β-Sitosterol for four weeks, from the age of seven months. Brain Aβ metabolism was evaluated using ELISA and Western blotting. We found that β-Sitosterol treatment can improve spatial learning and recognition memory ability, and reduce plaque load in APP/PS1 mice. β-Sitosterol treatment helped reverse dendritic spine loss in APP/PS1 mice and reversed the decreased hippocampal neuron miniature excitatory postsynaptic current frequency. Our research helps to explain and support the neuroprotective effect of β-Sitosterol, which may offer a novel pharmaceutical agent for the treatment of AD. Taken together, these findings suggest that β-Sitosterol ameliorates memory and learning impairment in APP/PS1 mice and possibly decreases Aβ deposition
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참고문헌 (32)
참고문헌 신청
Aprahamian I / 2013 / New treatment strategies for Alzheimer's disease: is there a hope? / Indian J Med Res 138:449~460
Zhang LH / 2008 / Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain / Brain Res Bull 77:55~60
Ma SL / 2012 / Prolyl isomerase Pin1promotes amyloid precursor protein(APP)turnover by inhibiting glycogen synthase kinase-3β(GSK3β)activity : novel mechanism for Pin1 to protect against Alzheimer disease / J Biol Chem 287:6969~6973
Bateman RJ / 2010 / Amyloid-beta production and clearance rates in Alzheimer's disease / J Alzheimer’s Assoc 6(Suppl):S101
Gordon MN / 2001 / Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice / Neurobiol Aging 22:377~385
Zhang LH / 2008 / Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain / Brain Res Bull 77:55~60
Ma SL / 2012 / Prolyl isomerase Pin1promotes amyloid precursor protein(APP)turnover by inhibiting glycogen synthase kinase-3β(GSK3β)activity : novel mechanism for Pin1 to protect against Alzheimer disease / J Biol Chem 287:6969~6973
Bateman RJ / 2010 / Amyloid-beta production and clearance rates in Alzheimer's disease / J Alzheimer’s Assoc 6(Suppl):S101
Gordon MN / 2001 / Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice / Neurobiol Aging 22:377~385
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