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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 104 - 104 (1page)
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초록· 키워드
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Introduction: Numerous studies have reported that, on one hand, age-related hearing loss (ARHL) may be a risk factor for dementia and Alzheimer’s disease (AD) and that, on the other hand, the auditory function in AD patients is damaged as their cognitive ability declines. Therefore, we investigated cognitive impairment and neuro-pathological changes in AD mouse model with induced hearing loss and with normal hearing mouse model after auditory and audio-visual stimulations.
Methods: In this study, the Apoetm1.1(APOE*4) Adiuj (ApoE4-KI) mice, which is a sporadic AD mice model, was used and hearing loss mice were exposed to white noise at 110dB sound pressure level (SPL) for 3 hours. Animal were divided into 3 groups (Noise-induced hearing loss and none stimulation in AD mice; ADHL-C, Noise-induced hearing loss and auditory stimulation in AD mice; ADHL-A, Noise-induced hearing loss and auditory-visual stimulation in AD mice; ADHL-AV. To confirm the hearing loss in AD mice, hearing function and thresholds were assessed by auditory brainstem response (ABR) and were recorded in a double-wall click sound. We pr ... 전체 초록 보기
Methods: In this study, the Apoetm1.1(APOE*4) Adiuj (ApoE4-KI) mice, which is a sporadic AD mice model, was used and hearing loss mice were exposed to white noise at 110dB sound pressure level (SPL) for 3 hours. Animal were divided into 3 groups (Noise-induced hearing loss and none stimulation in AD mice; ADHL-C, Noise-induced hearing loss and auditory stimulation in AD mice; ADHL-A, Noise-induced hearing loss and auditory-visual stimulation in AD mice; ADHL-AV. To confirm the hearing loss in AD mice, hearing function and thresholds were assessed by auditory brainstem response (ABR) and were recorded in a double-wall click sound. We pr ... 전체 초록 보기
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UCI(KEPA) : I410-ECN-0101-2021-528-001570180