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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제2호
- 발행연도
- 2020.1
- 수록면
- 149 - 156 (8page)
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Sodium 2-mercaptoethanesulfonate (mesna) is a protective agent that is widely used in medicine because of its antioxidant effects. Recently, reactive oxygen species (ROS) were shown to increase pigmentation. Thus, ROS scavengers and inhibitors of ROS production may suppress melanogenesis. Forkhead box-O3a (FoxO3a) is an antimelanogenic factor that mediates ROS-induced skin pigmentation. In this study, we aimed to investigate the whitening effect of mesna and the signaling mechanism mediating this effect. Human melanoma (MNT-1) cells were used in this study. mRNA and protein expression were measured by real-time quantitative PCR and Western blotting analysis to track changes in FoxO3a-related signals induced by mesna. An immunofluorescence assay was performed to determine the nuclear translocation of FoxO3a. When MNT-1 melanoma cells were treated with mesna, melanin production and secretion decreased. These effects were accompanied by increases in FoxO3a activation and nuclear translocation, resulting in downregulation of four master genes of melanogenesis: MITF, TYR, TRP1, and TRP2. We found that mesna, an antioxidant and radical scavenger, suppresses melanin production and may therefore be a useful agent for the clinical treatment of hyperpigmentation disorders
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참고문헌 (19)
참고문헌 신청
Masaki H / 2010 / Role of antioxidants in the skin : anti-aging effects / J Dermatol Sci 58:85~90
Meister A / 1994 / Glutathione-ascorbic acid antioxidant system in animals / J Biol Chem 269:9397~9400
Villarama CD / 2005 / Glutathione as a depigmenting agent : an overview / Int J Cosmet Sci 27:147~153
Kabasakal L / 2004 / Mesna(2-mercaptoethane sulfonate)prevents ischemia/reperfusion induced renal oxidative damage in rats / Life Sci 75:2329~2340
Yilmaz ER / 2013 / The protective effect of 2-mercaptoethane sulfonate(MESNA)against traumatic brain injury in rats / Acta Neurochir(Wien) 155:141~149
Meister A / 1994 / Glutathione-ascorbic acid antioxidant system in animals / J Biol Chem 269:9397~9400
Villarama CD / 2005 / Glutathione as a depigmenting agent : an overview / Int J Cosmet Sci 27:147~153
Kabasakal L / 2004 / Mesna(2-mercaptoethane sulfonate)prevents ischemia/reperfusion induced renal oxidative damage in rats / Life Sci 75:2329~2340
Yilmaz ER / 2013 / The protective effect of 2-mercaptoethane sulfonate(MESNA)against traumatic brain injury in rats / Acta Neurochir(Wien) 155:141~149
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