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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제4호
- 발행연도
- 2019.1
- 수록면
- 537 - 541 (5page)
이용수
초록· 키워드
오류제보하기
Objective: This study aimed to investigate the effectiveness and safety of bupropion extended-release for the treatment of depressive disorder in children and adolescents. Methods: This was a 12-week, retrospective chart review of bupropion, which included 127 youth (age, 15.3 ± 2.3 years; 66 boys) with depressive disorders (105 with major depressive disorder, 14 with dysthymia, 11 with adjustment disorder with depressed mood, and seven with depressive disorder not otherwise specified). Illness severity at baseline and at the 4th, 8th, and 12th weeks was retrospectively scored using the Clinical Global Impressions-Depression-Severity (CGI-Depression-S) and/or Clinical Global Impressions-Depression-Improvement (CGI-Depression-I). Results: The mean dose of bupropion was 180.0 ± 52.6 (range, 75−300) mg/day and the mean duration 33.9 ± 53.1 (range, 7−295) weeks. The CGI-Depression-S scores were significantly decreased over 12 weeks (F = 132.125, p ＜ 0.001, partial 2 = 0.508). Fifty-eight subjects (45.7%) were determined to be responders at 12 weeks (defined by a CGI-Depression-I score ≤ 2). Forty-six patients (36.2%) discontinued bupropion before the 12 weeks (19 due to adverse events, 15 due to poor effectiveness, three due to referral to other clinics, and nine due to follow-up loss for unknown reasons). Overall, bupropion was well tolerated. The most common adverse event was irritability (n = 12, 9.4%), which resolved spontaneously in eight subjects or after drug discontinuation in four subjects. Conclusion: Our results provide preliminary evidence of the effectiveness and safety of bupropion in children and adolescents with depressive episodes. Large, prospective, placebo-controlled studies are needed to confirm these findings.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Rey J / Textbook of child and adolescent mental health / International Association for Child and Adolescent Psychiatry and Allied Professionals
Berigan TR / 2002 / The Many uses of bupropion and bupropion sustained release(SR)in adults / Prim Care Companion J Clin Psychiatry 4:30~32
Milea D / 2010 / Prescription patterns of antidepressants : findings from a US claims database / Curr Med Res Opin 26:1343~1353
남범우 / 2017 / Comparing the Effects of Bupropion and Escitalopram on Excessive Internet Game Play in Patients with Major Depressive Disorder / Clinical Psychopharmacology and Neuroscience 15(4):361~368
Rush AJ / 2006 / Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression / N Engl J Med 354:1231~1242
Berigan TR / 2002 / The Many uses of bupropion and bupropion sustained release(SR)in adults / Prim Care Companion J Clin Psychiatry 4:30~32
Milea D / 2010 / Prescription patterns of antidepressants : findings from a US claims database / Curr Med Res Opin 26:1343~1353
남범우 / 2017 / Comparing the Effects of Bupropion and Escitalopram on Excessive Internet Game Play in Patients with Major Depressive Disorder / Clinical Psychopharmacology and Neuroscience 15(4):361~368
Rush AJ / 2006 / Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression / N Engl J Med 354:1231~1242
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