지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제18권 제1호
- 발행연도
- 2020.1
- 수록면
- 127 - 135 (9page)
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초록· 키워드
오류제보하기
Objective: Mismatch negativity (MMN) is known to be associated with neuro-cognition and functional outcomes. Remission and recovery rates are related to the neuro-cognition of patients with schizophrenia. The present study explored the relationship of MMN with remission in patients with schizophrenia. Methods: Forty patients with schizophrenia were recruited and divided into two groups, with or without remission, according to the Remission in Schizophrenia Working Group criteria (RSWGcr). Symptom severity (Positive and Negative Syndrome Scale, PANSS), cognitive function, functional outcome, and MMN of the patients were evaluated. A regression analysis was used to identify the factors that significantly predicted symptom improvement and remission including MMN at frontal site assessed at baseline, and anticipated clinical variables as predictive factors. Results: MMN amplitudes in frontal sites were further decreased in the groups without remission compared to the groups with remission. MMN amplitude was significantly correlated with measures of symptom change and functional outcome measurements in patients with schizophrenia. Regression analysis revealed that symptom severity and MMN significantly predicted remission in patients with schizophrenia. Symptom improvement significantly predicted PANSS at baseline, illness duration, and antipsychotic dose, as did MMN amplitude at frontal site. Conclusion: Our results suggest that MMN reflected symptom improvement and remission in patients with schizophrenia. MMN indices appear to be promising candidates as predictive factors for schizophrenia remission.
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등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Jeong Ha Park / 2019 / Effects of Amisulpride Adjunctive Therapy on Working Memory and Brain Metabolism in the Frontal Cortex of Patients with Schizophrenia: A Preliminary Positron Emission Tomography/ Computerized Tomography Investigation / Clinical Psychopharmacology and Neuroscience 17(2):250~260
Harvey PD / 2009 / Toward a terminology for functional recovery in schizophrenia: is functional remission a viable concept? / Schizophr Bull 35:300~306
Nasrallah HA / 2006 / Improving patient outcomes in schizophrenia : achieving remission / J Psychopharmacol 20(6 Suppl):57~61
Bodén R / 2009 / Association between symptomatic remission and functional outcome in first-episode schizophrenia / Schizophr Res 107:232~237
Brissos S / 2011 / Symptomatic remission in schizophrenia patients : relationship with social functioning, quality of life, and neurocognitive performance / Schizophr Res 129:133~136
Harvey PD / 2009 / Toward a terminology for functional recovery in schizophrenia: is functional remission a viable concept? / Schizophr Bull 35:300~306
Nasrallah HA / 2006 / Improving patient outcomes in schizophrenia : achieving remission / J Psychopharmacol 20(6 Suppl):57~61
Bodén R / 2009 / Association between symptomatic remission and functional outcome in first-episode schizophrenia / Schizophr Res 107:232~237
Brissos S / 2011 / Symptomatic remission in schizophrenia patients : relationship with social functioning, quality of life, and neurocognitive performance / Schizophr Res 129:133~136
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