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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제49권 제6호
- 발행연도
- 2019.1
- 수록면
- 635 - 641 (7page)
이용수
초록· 키워드
오류제보하기
Hydrogels show great potential particularly in the development of drug delivery because of their desirable properties. The enzymatic crosslinked casein hydrogel is a new generation and has received great attention for drug delivery. In the present study, the enzymatic crosslinked casein hydrogel containing insulin was prepared and in vitro and in vivo evaluations were assessed. The hydrogels were also evaluated using differential scanning calorimeter; X-ray diffraction; Scanning electron microscopy and Atomic force microscopy methods. The rheological and releasing behaviors at different media were also investigated. The secondary structure of insulin was assayed by CD method and finally, the hypoglycemic effects were tested in the diabetic rats. Hydrogel showed a three-dimensional porous structure. Rheographs indicated the combination of thixotropic and pseudoplastic behaviors. In vitro release studies confirmed that insulin released in acidic condition slowly, however, in neutral and alkaline environments insulin rapidly released. The structure of insulin preserved following release. Hypoglycemic effects were observed by oral administration of insulin-loaded hydrogel. Thus, the enzymatic crosslinked hydrogel can be considered as a good candidate for oral delivery of insulin.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Abdelmoneem MA / 2018 / Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma / J Control Release 287:78~93
Abe H / 2010 / Enzymatic single-step preparation of multifunctional proteins / Chem Commun (Camb) 46:7160~7162
Abu H / 2010 / Potential use of gamma-cyclodextrin polypseudorotaxane hydrogels as an injectable sustained release system for insulin / Int J Pharm 392:83~91
Alibolandi M / 2016 / Dextran-bpoly(lactide-co-glycolide)polymersome for oral delivery of insulin : in vitro and in vivo evaluation / J Control Release 227:58~70
Chen S-C / 2004 / A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate crosslinked by genipin for protein drug delivery / J Control Release 96:285~300
Abe H / 2010 / Enzymatic single-step preparation of multifunctional proteins / Chem Commun (Camb) 46:7160~7162
Abu H / 2010 / Potential use of gamma-cyclodextrin polypseudorotaxane hydrogels as an injectable sustained release system for insulin / Int J Pharm 392:83~91
Alibolandi M / 2016 / Dextran-bpoly(lactide-co-glycolide)polymersome for oral delivery of insulin : in vitro and in vivo evaluation / J Control Release 227:58~70
Chen S-C / 2004 / A novel pH-sensitive hydrogel composed of N, O-carboxymethyl chitosan and alginate crosslinked by genipin for protein drug delivery / J Control Release 96:285~300
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