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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 236 - 242 (7page)
- DOI
- 10.1186/s40824-016-0078-y
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초록· 키워드
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Background: Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not electrically conductive and thus their electrical communication with biological systems is limited. Method: To create electrically conductive hydrogels, we fabricated composite hydrogels of hyaluronic acid and polypyrrole. In particular, we synthesized and used pyrrole-hyaluronic acid-conjugates and further chemically polymerized polypyrrole with the conjugates for the production of conductive hydrogels that can display suitable mechanical and structural properties. Results: Various characterization methods, using a rheometer, a scanning electron microscope, and an electrochemical analyzer, revealed that the PPy/HA hydrogels were soft and conductive with ~ 3 kPa Young’s modulus and ~ 7.3 mS/cm conductivity. Our preliminary in vitro culture studies showed that fibroblasts were well attached and grew on the conductive hydrogels. Conclusion: These new conductive hydrogels will be greatly beneficial in fields of biomaterials in which electrical properties are important such as tissue engineering scaffolds and prosthetic devices.
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참고문헌 (28)
참고문헌 신청
O’brien FJ / 2011 / Biomaterials & scaffolds for tissue engineering / Mater Today 14:88~95
Hardy JG / 2013 / Biomimetic conducting polymer-based tissue scaffolds / Curr Opin Biotechnol 24:847~854
Balint R / 2014 / Conductive polymers : Towards a smart biomaterial for tissue engineering / Acta Biomater 10:2341~2353
Pires F / 2015 / Neural stem cell differentiation by electrical stimulation using a cross-linked PEDOT substrate : expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering / Biochim Biophys Acta BBA-Gen Subj 1850:1158~1168
Green RA / 2016 / Conducting polymerhydrogels for medical electrode applications / Sci Technol Adv Mater
Hardy JG / 2013 / Biomimetic conducting polymer-based tissue scaffolds / Curr Opin Biotechnol 24:847~854
Balint R / 2014 / Conductive polymers : Towards a smart biomaterial for tissue engineering / Acta Biomater 10:2341~2353
Pires F / 2015 / Neural stem cell differentiation by electrical stimulation using a cross-linked PEDOT substrate : expanding the use of biocompatible conjugated conductive polymers for neural tissue engineering / Biochim Biophys Acta BBA-Gen Subj 1850:1158~1168
Green RA / 2016 / Conducting polymerhydrogels for medical electrode applications / Sci Technol Adv Mater
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