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논문 기본 정보

자료유형
학술저널
저자정보
Wenqian Zhang (Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology) Kangkang Zha (Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology) Weixian Hu (Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology) Yuan Xiong (Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology) Samuel Knoedler (Division of Plastic Surgery Brigham and Women’s Hospital Harvard Medical School) Doha Obed (Division of Plastic Surgery Brigham and Women’s Hospital Harvard Medical School) Adriana C. Panayi (Department of Hand Plastic and Reconstructive Surgery Microsurgery Burn Center BG Trauma Center Ludwigshafen University of Heidelberg) Ze Lin (Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology) Faqi Cao (Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology) Bobin Mi (Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology) Guohui Liu (Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
1,861 - 1,886 (26page)
DOI
https://doi.org/10.1186/s40824-023-00411-9

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Various joint pathologies such as osteochondritis dissecans, osteonecrosis, rheumatic disease, and trauma, may result in severe damage of articular cartilage and other joint structures, ranging from focal defects to osteoarthritis (OA). The osteochondral unit is one of the critical actors in this pathophysiological process. New approaches and applications in tissue engineering and regenerative medicine continue to drive the development of OA treatment. Hydrogel scaffolds, a component of tissue engineering, play an indispensable role in osteochondral regeneration. In this review, tissue engineering strategies regarding osteochondral regeneration were highlighted and summarized. The application of hydrogels for osteochondral regeneration within the last five years was evaluated with an emphasis on functionalized physical and chemical properties of hydrogel scaffolds, functionalized delivery hydrogel scaffolds as well as functionalized intelligent response hydrogel scaffolds. Lastly, to serve as guidance for future efforts in the creation of bioinspired hydrogel scaffolds, a succinct summary and new views for specific mechanisms, applications, and existing limitations of the newly designed functionalized hydrogel scaffolds were offered.

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