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논문 기본 정보

자료유형
학술저널
저자정보
Yinyue Luo (Department of Preventive Dentistry Shanghai Stomatological Hospital & School of Stomatology Department of Macromolecular Science Fudan University) Menglin Xiao (Department of Preventive Dentistry Shanghai Stomatological Hospital & School of Stomatology Department of Macromolecular Science Fudan University) Bushra sufyan Almaqrami (Department of Orthodontics Ningbo Dental Hospital) Hong Kang (Department of Temporomandibular Joint and Occlusion School/Hospital of Stomatology Lanzhou University) Zhengzhong Shao (Department of Preventive Dentistry Shanghai Stomatological Hospital & School of Stomatology Department of Macromolecular Science Fudan University) Xin Chen (Department of Preventive Dentistry Shanghai Stomatological Hospital & School of Stomatology Department of Macromolecular Science Fudan University) Ying Zhang (Department of Preventive Dentistry Shanghai Stomatological Hospital & School of Stomatology Department of Macromolecular Science Fudan University)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
1,380 - 1,396 (17page)
DOI
https://doi.org/10.1186/s40824-023-00370-1

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BackgroundOsteochondral defects pose an enormous challenge without satisfactory repair strategy to date. In particular, the lateral integration of neo-cartilage into the surrounding native cartilage is a difficult and inadequately addressed problem determining tissue repair’s success. MethodsRegenerated silk fibroin (RSF) based on small aperture scaffolds was prepared with n-butanol innovatively. Then, the rabbit knee chondrocytes and bone mesenchymal stem cells (BMSCs) were cultured on RSF scaffolds, and after induction of chondrogenic differentiation, cell-scaffold complexes strengthened by a 14 wt% RSF solution were prepared for in vivo experiments. ResultsA porous scaffold and an RSF sealant exhibiting biocompatibility and excellent adhesive properties are developed and confirmed to promote chondrocyte migration and differentiation. Thus, osteochondral repair and superior horizontal integration are achieved in vivo with this composite. ConclusionsOverall, the new approach of marginal sealing around the RSF scaffolds exhibits preeminent repair results, confirming the ability of this novel graft to facilitate simultaneous regeneration of cartilage–subchondral bone.

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