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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 15 - 15 (1page)
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Introduction. Cartilage tissue suffers from the lack of vasculature, which restricted its self-regeneration by a slow proliferation of chondrocytes and neo-matrix reconstruction. Among all various treatments for the regeneration of osteochondral defects, cell-based therapy has been attracted huge interest among researchers due to its high capability of cartilage regeneration. In this method, the engineering of scaffolds that can provide a microenvironment similar to a native tissue is of great significance. In this study, the cartilage regeneration capacity of cartilage-based extracellular matrix (ChECM)-immobilized polymeric nanofibrils, followed by self-assembling adipose-derived stem cells (ADSCs), was investigated.
Method. Firstly, the surface of PCL-based nanofibrils (NFs) was chemically modified by ECM obtained by decellularizing cartilage tissue. Then, adipose-derived stem cells (ADSCs) were attached to the surface of modified NFs via cell-directed as^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10554002');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
Method. Firstly, the surface of PCL-based nanofibrils (NFs) was chemically modified by ECM obtained by decellularizing cartilage tissue. Then, adipose-derived stem cells (ADSCs) were attached to the surface of modified NFs via cell-directed as^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10554002');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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UCI(KEPA) : I410-ECN-0101-2021-515-001700229