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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 75 - 84 (10page)
- DOI
- 10.1186/s40824-018-0118-x
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초록· 키워드
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Background: Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is recommended as a novel biotherapeutic protein that restore functional articular cartilage. Likewise, malfunction of lubrication in damaged articular cartilage caused by complex and multifaceted matter is a major concern in the field of cartilage tissue engineering. Main body: Although a noticeable progress has been made toward cartilage tissue regeneration through numerous approaches such as autologous chondrocyte implantation, osteochondral grafts, and microfracture technique, the functionality of engineered cartilage is a challenge for complete reconstruction of cartilage. Thus, delicate modulation of lubricin along with cell/scaffold application will expand the research on cartilage tissue engineering. Conclusion: In this review, we will discuss the empirical analysis of lubricin from fundamental interpretation to the practical design of gene expression regulation.
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등록된 정보가 없습니다.
참고문헌 (89)
참고문헌 신청
Kim IL / 2011 / Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid / Biomaterials 32(34):8771~8782
Ciullini Mannurita S / 2014 / CACP syndrome: identification of five novel mutations and of the first case of UPD in the largest European cohort / Eur J Hum Genet 22(2):197~201
Galle J / 2010 / Mesenchymal Stem Cells in Cartilage Repair: State of the Art and Methods to monitor Cell Growth, Differentiation and Cartilage Regeneration / Curr Med Chem 17(21):2274~2291
Bedi A / 2010 / Management of articular cartilage defects of the knee / J Bone Joint Surg Am 92(4):994~1009
Chung C / 2008 / Engineering cartilage tissue / Adv Drug Deliv Rev 60(2):243~262
Ciullini Mannurita S / 2014 / CACP syndrome: identification of five novel mutations and of the first case of UPD in the largest European cohort / Eur J Hum Genet 22(2):197~201
Galle J / 2010 / Mesenchymal Stem Cells in Cartilage Repair: State of the Art and Methods to monitor Cell Growth, Differentiation and Cartilage Regeneration / Curr Med Chem 17(21):2274~2291
Bedi A / 2010 / Management of articular cartilage defects of the knee / J Bone Joint Surg Am 92(4):994~1009
Chung C / 2008 / Engineering cartilage tissue / Adv Drug Deliv Rev 60(2):243~262
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