Regulation of Cartilage Development and Diseases by Transcription Factors

Riko Nishimura; Kenji Hata; Yoshifumi Takahata; Tomohiko Murakami; Eriko Nakamura; Hiroko Yagi

doi:https://doi.org/10.11005/jbm.2017.24.3.147

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자료유형: 학술저널

저자정보: Riko Nishimura (Osaka University Graduate School of Dentistry) Kenji Hata (Osaka University Graduate School of Dentistry) Yoshifumi Takahata (Osaka University Graduate School of Dentistry) Tomohiko Murakami (Osaka University Graduate School of Dentistry) Eriko Nakamura (Osaka University Graduate School of Dentistry) Hiroko Yagi (Osaka University Graduate School of Dentistry)

저널정보: 대한골대사학회 대한골대사학회지 대한골대사학회지 제24권 제3호

발행연도: 2017.8

수록면: 147 - 153 (7page)

DOI: https://doi.org/10.11005/jbm.2017.24.3.147

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Genetic studies and molecular cloning approaches have been successfully used to identify several transcription factors that regulate the numerous stages of cartilage development. Sex-determining region Y (SRY)-box 9 (Sox9) is an essential transcription factor for the initial stage of cartilage development. Sox5 and Sox6 play an important role in the chondrogenic action of Sox9, presumably by defining its cartilage specificity. Several transcription factors have been identified as transcriptional partners for Sox9 during cartilage development. Runt-related transcription factor 2 (Runx2) and Runx3 are necessary for hypertrophy of chondrocytes. CCAAT/enhancer-binding protein β (C/EBPβ) and activating transcription factor 4 (ATF4) function as co-activators for Runx2 during hypertrophy of chondrocytes. In addition, myocyte-enhancer factor 2C (Mef2C) is required for initiation of chondrocyte hypertrophy, presumably by functioning upstream of Runx2. Importantly, the pathogenic roles of several transcription factors in osteoarthritis have been demonstrated based on the similarity of pathological phenomena seen in osteoarthritis with chondrocyte hypertrophy. We discuss the importance of investigating cellular and molecular properties of articular chondrocytes and degradation mechanisms in osteoarthritis, one of the most common cartilage diseases.

#Cartilage #Chondrocytes #Osteoarthritis #Transcription factors

참고문헌 (45)

참고문헌 신청

Nishimura R / 2012 / Regulation of bone and cartilage development by network between BMP signalling and transcription factors / J Biochem 151:247~254

Kenji Hata / 2017 / Transcriptional Network Controlling Endochondral Ossification / 대한골대사학회지 24(2):75~82

Akiyama H / 2002 / The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 / Genes Dev 16:2813~2828

Foster JW / 1994 / Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene / Nature 372:525~530

Wagner T / 1994 / Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9 / Cell 79:1111~1120

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