지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Endochondral ossification is the fundamental process of skeletal development in vertebrates. Chondrocytes undergo sequential steps of differentiation, including mesenchymal condensation, proliferation, hypertrophy, and mineralization. These steps, which are required for the morphological and functional changes in differentiating chondrocytes, are strictly regulated by a complex transcriptional network. Biochemical and mice genetic studies identified chondrogenic transcription factors critical for endochondral ossification. The transcription factor sex-determining region Y (SRY)-box 9 (Sox9) is essential for early chondrogenesis, and impaired Sox9 function causes severe chondrodysplasia in humans and mice. In addition, recent genome-wide chromatin immunoprecipitation-sequencing studies revealed the precise regulatory mechanism of Sox9 during early chondrogenesis. Runt-related transcription factor 2 promotes chondrocyte hypertrophy and terminal differentiation. Interestingly, endoplasmic reticulum (ER) stress-related transcription factors have recently emerged as novel regulators of chondrocyte differentiation. Here we review the transcriptional mechanisms that regulate endochondral ossification, with a focus on Sox9.
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참고문헌 (23)
참고문헌 신청
Akiyama H / 2002 / The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 an
Akiyama H / 2007 / Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice / Matrix Biol 26 : 224 ~ 233
Amano K / 2011 / Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcriptio
Bandyopadhyay A / 2006 / Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis / PLoS Genet 2 : e216 ~
Bell DM / 1997 / SOX9 directly regulates the type-II collagen gene / Nat Genet 16 : 174 ~ 178
Akiyama H / 2007 / Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice / Matrix Biol 26 : 224 ~ 233
Amano K / 2011 / Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcriptio
Bandyopadhyay A / 2006 / Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis / PLoS Genet 2 : e216 ~
Bell DM / 1997 / SOX9 directly regulates the type-II collagen gene / Nat Genet 16 : 174 ~ 178
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