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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 385 - 395 (11page)
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Polyinosinic:polycytidylic acid (poly[I:C]) can stimulate Toll-like receptor 3 (TLR3) signaling pathways. In this study, DF-1 cells were treated with poly(I:C) at various concentrations and time points to examine the comparative expression patterns of innate immune response genes. The viability of DF-1 cells decreased from 77.41% to 38.68% when cells were treated different dose of poly(I:C) from 0.1 μg/mL to 100 μg/mL for 24 h respectively. The expressions of TLR3, TLR4, TLR7, TLR15, TLR21, IL1B, and IL10 were increased in dose- and time-dependent manners by poly(I:C) treatment. On the contrary, the expression patterns of interferon regulatory factors 7 (IRF7), Jun proto-oncogene, AP-1 transcription factor subunit (JUN), Nuclear Factor Kappa B Subunit 1 (NF-κB1), and IL8L2 were varied; IRF7 and IL8L2 were increasingly expressed whereas the expressions of JUN and NF-κB1 were decreased in a dose-dependent manner after they were early induced. In time-dependent analysis, IRF7 expression was significantly upregulated from 3 h to 24 h, whereas JUN and NF-κB1 expressions settled down from 6 h to 24 h after poly(I:C) treatment although they were induced at early time from 1 h to 3 h. Poly(I:C) treatment rapidly increased the expression of IL8L2 from 3 h to 6 h with a plateau at 6 h and then the expression of IL8L2 was dramatically decreased until 24 h after poly(I:C) treatment although the expression level was still higher than the non-treated control. These results may provide the basis for understanding host response to viral infection and its mimicry system in chickens.
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참고문헌 (54)
참고문헌 신청
Riera Romo M / 2016 / Innate immunity in vertebrates : an overview / Immunology 148:125~139
Thompson MR / 2011 / Pattern recognition receptors and the innate immune response to viral infection / Viruses 3:920~940
Roers A / 2016 / Recognition of endogenous nucleic acids by the innate immune system / Immunity 44:739~754
Majer O / 2017 / Nucleic acid-sensing TLRs : trafficking and regulation / Curr Opin Immunol 44:26~33
Oldenburg M / 2012 / TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification / Science 337:1111~1115
Thompson MR / 2011 / Pattern recognition receptors and the innate immune response to viral infection / Viruses 3:920~940
Roers A / 2016 / Recognition of endogenous nucleic acids by the innate immune system / Immunity 44:739~754
Majer O / 2017 / Nucleic acid-sensing TLRs : trafficking and regulation / Curr Opin Immunol 44:26~33
Oldenburg M / 2012 / TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification / Science 337:1111~1115
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