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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 312 - 318 (7page)
- DOI
- 10.9799/ksfan.2017.30.2.312
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초록· 키워드
오류제보하기
Aloe-emodin (AE) is the major bioactive component in aloe and known to exhibit anti-inflammatory activities. However, it has not been elucidated whether its anti-inflammatory potency can contribute to the elimination of obesity. The aim of the current study is to investigate the effect of AE on toll-like receptor 4 (TLR4) pathways in the presence of lipopolysaccharide (LPS) in 3T3-L1 adipocytes. 3T3-L1 adipocytes were treated with AE (0-20 μM) for one hour, followed by LPS treatment for 30 min and then, adipokine mRNA expression levels were measured. Next, TLR4-related molecules were measured in LPS-stimulated 3T3-L1 adipocytes. AE significantly decreased the mRNA expression of the tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) in a dose-dependent manner. Moreover, AE suppressed TLR4 mRNA expression. Further study showed that AE could suppress the nuclear factor-κB (NF-κB) and phosphorylation of extracellular receptor-activated kinase (pERK). The results of this study suggest that AE directly inhibits TLR4/NF-κB/ERK signaling pathways and decreases the inflammatory response in adipocytes.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Andersen DO / 1991 / In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives / Antiviral Res 16:185~196
Anderson PD / 2007 / Innate immunity modulates adipokines in humans / J Clin Endocrinol Metab 92:2272~2279
Arosio B / 2000 / Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride / Pharmacol Toxicol 87:229~233
Barbarroja N / 2010 / The obese healthy paradox: is inflammation the answer? / Biochem J 430:141~149
Cani PD / 2007 / Metabolic endotoxemia initiates obesity and insulin resistance / Diabetes 56:1761~1772
Anderson PD / 2007 / Innate immunity modulates adipokines in humans / J Clin Endocrinol Metab 92:2272~2279
Arosio B / 2000 / Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride / Pharmacol Toxicol 87:229~233
Barbarroja N / 2010 / The obese healthy paradox: is inflammation the answer? / Biochem J 430:141~149
Cani PD / 2007 / Metabolic endotoxemia initiates obesity and insulin resistance / Diabetes 56:1761~1772
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