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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 79 - 84 (6page)
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Purpose: Hyaluronidase (HAase) has many uses in medicine, and reports suggest that it affects perineal tissue during fetal passagethrough the vaginal canal. However, its potential use for preventing perineal trauma has yet to be determined. This study sought toevaluate the efficacy and safety of perineal HAase injections in reducing perineal trauma during vaginal delivery. Materials and Methods: A multi-center, double-blind, placebo-controlled, randomized study was conducted from January 2016 toMarch 2017. Nulliparous women who planned to undergo vaginal delivery were recruited, and the enrolled women were randomlyassigned to the HAase injection group (HAase injection, 5000 IU, n=75) or the control group (normal saline injection, n=73). Thedegree of perineal laceration, rate of episiotomy, and grade of perineal edema at 1 hour and 24 hours after spontaneous vaginal deliverywere compared between the two groups. Results: A total of 148 women who underwent vaginal delivery were recruited. No significant differences were observed betweenthe HAase injection and control groups in the rates of perineal laceration (p=0.422). Perineal edema significantly decreased 24hours after delivery in the women treated with perineal HAase injections, compared to women in the control group (p=0.008). Theoverall incidences of adverse events, such as redness of the injection site, infection, and wound dehiscence, were similar betweenthe two groups. Conclusion: HAase injections in nulliparous women afforded no reductions in the rates of perineal lacerations and episiotomy. However, the use of perineal HAase injections did reduce perineal edema without severe adverse events.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Baumann P / 2007 / Factors associated with anal sphincter laceration in 40, 923 primiparous women / Int Urogynecol J Pelvic Floor Dysfunct 18:985~990
Fernando RJ / 2013 / Methods of repair for obstetric anal sphincter injury / Cochrane Database Syst Rev (12):CD002866
Frohlich J / 2015 / Perineal care / BMJ Clinl Evid
Marschalek ML / 2018 / Risk and protective factors for obstetric anal sphincter injuries : a retrospective nationwide study / Birth 45:409~415
Pauls RN / 2007 / Sexual function following anal sphincteroplasty for fecal incontinence / Am J Obstet Gynecol 197:618
Fernando RJ / 2013 / Methods of repair for obstetric anal sphincter injury / Cochrane Database Syst Rev (12):CD002866
Frohlich J / 2015 / Perineal care / BMJ Clinl Evid
Marschalek ML / 2018 / Risk and protective factors for obstetric anal sphincter injuries : a retrospective nationwide study / Birth 45:409~415
Pauls RN / 2007 / Sexual function following anal sphincteroplasty for fecal incontinence / Am J Obstet Gynecol 197:618
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