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Firefighters have a high risk of developing cardiovascular and mental disorders due to their physical and chemical environments. However, in Korea, few studies have been conducted on environmental risk of firefighters. The Firefighter Research on the Enhancementof Safety and Health (FRESH) study aimed to discover the risk factors for cardiovascular disease and mental disordersamong firefighters. Former and current firefighters were recruited from three university hospitals. A total of 1022 participantscompleted baseline health examinations from 2016 to 2017. All participants were scheduled for follow-ups every 2 years. Baselinehealth survey, laboratory testing of blood and urine samples, blood heavy metal concentration, urine polycyclic aromatic hydrocarbons(PAHs) metabolites, stress-related hormone test, natural killer cell activity, as well as physical and mental health examinationsthat focused on cardiovascular and mental disorders, were conducted. In addition, 3 Tesla (3T) brain magnetic resonanceimaging (MRI) and neuropsychological tests were also performed to investigate structural and functional changes in the brains of352 firefighters aged >40 years or new hires with less than 1 year of service.

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