지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제21권 제2호
- 발행연도
- 2020.1
- 수록면
- 79 - 90 (12page)
이용수
초록· 키워드
오류제보하기
Radioisotope ADME (RI-ADME) studies are enabling visualization of the biodistribution in molecular imaging. We applied RI-ADME to investigate the tumor targeting capacity and biodistribution of trastuzumab-monomethyl auristatin F (LCB14-0110) in JIMT-1 xenograft mice and healthy marmoset. The LCB14-0110 was labelled with 125I. 125I-LCB14-0110 was intravenously administered to the animals. The gamma-count and single-photon emission computed tomography/computed tomography (SPECT/CT) was conducted for biodistributioon and bioimaging of the biopharmaceutics. Tumor uptake in xenograft mice was highest at three-day after 125I-LCB14-0110 administration in both the biodistribution and SPECT/CT bioimaging. Alternatively, blood and organ tissues showed gradual decrease in radioactivity over time. In marmosets, radioactivity in all organ tissues rapidly reduced and no specific targeting of organs was observed in the biodistribution study and SPECT/CT imaging. Hence, 125I- LCB14-0110 demonstrated effective tumor targeting capacity and accumulated in JIMT-1 cell-bearing mice. However, accumulation did not occur in the organs of xenograft mice. Additionally, marmosets showed rapidly decrease in radioactivity throughout the entire body without accumulation in the normal organs. We also confirmed that the drug distribution was similar in normal organs between the two experimental animal species except spleen. Therefore, 125I is expected to be a useful tool in the study of RI-ADME in biopharmaceuticals through minimal antibody modification.
목차
등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
Dalvie D / 2000 / Recent advances in the applications of radioisotopes in drug metabolism, toxicology and pharmacokinetics / Curr Pharm Des 6:1009~1028
Xu X / 2012 / Challenges and opportunities in absorption, distribution, metabolism, and excretion studies of therapeutic biologics / AAPS J 14:781~791
Waaijer SJH / 2018 / Molecular imaging in cancer drug development / J Nucl Med 59:726~732
Morais M / 2018 / Site-specific chelator-antibody conjugation for PET and SPECT imaging with radiometals / Drug Discov Today Technol 30:91~104
Hillman EMC / 2011 / In vivo optical imaging and dynamic contrast methods for biomedical research / Philos Trans A Math Phys Eng Sci 369:4620~4643
Xu X / 2012 / Challenges and opportunities in absorption, distribution, metabolism, and excretion studies of therapeutic biologics / AAPS J 14:781~791
Waaijer SJH / 2018 / Molecular imaging in cancer drug development / J Nucl Med 59:726~732
Morais M / 2018 / Site-specific chelator-antibody conjugation for PET and SPECT imaging with radiometals / Drug Discov Today Technol 30:91~104
Hillman EMC / 2011 / In vivo optical imaging and dynamic contrast methods for biomedical research / Philos Trans A Math Phys Eng Sci 369:4620~4643
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Case report : marmoset wasting syndrome - diffuse inflammation in the abdominal organs of common marmoset
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Development of fundamental production technology for marmoset as a human disease model animal
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Toward national upgrade of in vivo animal experiments in drug development and evaluation
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Establishment and maintenance of SNUH marmoset model network center
한국실험동물학회 학술발표대회 논문집
2021 .07
-
MR neuroimaging of disease models in the common marmoset
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Generation of immortalized marmoset fibroblast cell lines by a CRISPR-Cas9-mediated gene targeting
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Surgical Stabilization of Femoral Fracture in a Common Marmoset (Callithrix Jacchus)
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Improvement artificial-feeding strategy of common marmoset triplets in Seoul National University Hospital
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Translational research for retinopathy using marmoset
한국실험동물학회 학술발표대회 논문집
2022 .07
-
[LS2] Validation of operations, facilities, and equipment for animal (marmoset) biosafety level 3 facility approval
한국실험동물학회 학술발표대회 논문집
2024 .07
-
Use of marmosets as a non-human primates (NHP) model for new drug development
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Development of genetically engineered marmoset models of early onset Alzheimer’s disease: initial experiences
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Fluorescence bioimaging analysis of collagen antibody-induced arthritis in male mice
Journal of Biomedical and Translational Research
2017 .12
-
Mouse models in cancer research
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Ectopic pregnancy in common marmoset (Case report)
한국실험동물학회 학술발표대회 논문집
2023 .02
-
In vivo molecular imaging in preclinical research
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Development of genetic markers in common marmoset
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Evaluation of in vivo biodistribution using fluorescent probe labeled microplastic
한국실험동물학회 학술발표대회 논문집
2021 .07
-
A computerized method for measuring xenograft tumor volume enhances the accuracy and consistency of tumor size assessment in xenograft cancer models
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Prenatal sonography implication of ocular development in common marmoset (Callithrix jacchus)
한국실험동물학회 학술발표대회 논문집
2021 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0