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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 387 - 394 (8page)
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초록· 키워드
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Background/Aims: Recent advances in understanding the genetics of pancreatic ductal adenocarcinoma (PDAC) have led to the potential for a personalized approach. Several studies have described the feasibility of generating genetic profiles of PDAC with next-generation sequencing (NGS) of samples obtained through endoscopic ultrasound-guided tissue acquisition (EUS-TA). The aim of this study was to find the best EUS-TA approach for successful NGS of PDAC. Methods: We attempted to perform NGS with tissues from 190 patients with histologically proven PDAC by endoscopic ultrasound-guided fine-needle aspiration and endoscopic ultrasound-guided fine-needle biopsy at Samsung Medical Center between November 2011 and February 2015. The medical records of these patients were retrospectively reviewed for parameters including tumor factors (size, location, and T stage), EUS-TA factors (needle gauge [G], needle type, and number of needle passes) and histologic factors (cellularity and blood contamination). The sample used for NGS was part of the EUS-TA specimen that underwent cytological and histological analysis. Results: NGS could be successfully performed in 109 patients (57.4%). In the univariate analysis, a large needle G (p=0.003) and tumor located in the body/tail (p=0.005) were associated with successful NGS. The multivariate logistic regression analysis revealed that the needle G was an independent factor of successful NGS (odds ratio, 2.19; 95% confidence interval, 1.08 to 4.47; p=0.031). Conclusions: The needle G is an independent factor associated with successful NGS. This finding may suggest that the quantity of cells obtained from EUS-TA specimens is important for successful NGS.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Jemal A / 2010 / Cancer statistics, 2010 / CA Cancer J Clin 60:277~300
Mayo SC / 2012 / Management of patients with pancreatic adenocarcinoma : national trends in patient selection, operative management, and use of adjuvant therapy / J Am Coll Surg 214:33~45
Mayo SC / 2010 / Adjuvant therapy and survival after resection of pancreatic adenocarcinoma : a population-based analysis / Cancer 116:2932~2940
김용태 / 2008 / 췌장암의 항암화학요법 / 대한소화기학회지 51(2):111~118
Peyvandi F / 2016 / Caplacizumab for acquired thrombotic thrombocytopenic purpura / N Engl J Med 374:511~522
Mayo SC / 2012 / Management of patients with pancreatic adenocarcinoma : national trends in patient selection, operative management, and use of adjuvant therapy / J Am Coll Surg 214:33~45
Mayo SC / 2010 / Adjuvant therapy and survival after resection of pancreatic adenocarcinoma : a population-based analysis / Cancer 116:2932~2940
김용태 / 2008 / 췌장암의 항암화학요법 / 대한소화기학회지 51(2):111~118
Peyvandi F / 2016 / Caplacizumab for acquired thrombotic thrombocytopenic purpura / N Engl J Med 374:511~522
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