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논문 기본 정보

자료유형
학술저널
저자정보
고은태 (Dept. of Oriental Medicine Graduate school SangJi University) 하지용 (Dept. of Oriental Medicine Graduate School SangJi University) 이선구 (Dept. of Oriental Medicine Graduate School SangJi University) 유병길 (Dept. of Oriental Medicine Graduate School SangJi University)
저널정보
대한암한의학회 대한한방종양학회지 대한한방종양학회지 제6권 제1호
발행연도
2000.1
수록면
29 - 45 (17page)

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In order to investigate the antitumor effect by Dangguihwalhyultang after B-l6 cells were transplanted in C57BL/6 mice, and the immune responses in mice induced by methotrexate, the extract of Dangguihwalhyultang was orally administered to the ICR mice. Experimental studies were performed for measurance of metastasis, cell cytotoxicity in vitro, life extention, weight of cancer, natural killer cell activity. productivity of interleukin-2. The results were summarized as follows: 1. Mean survival time in Dangguihwalhyultang-treated group was prolonged, as compared with control group(14.63%) significantly(P<0.05). 2. Inhibition of metastasis in Dangguihwalhyultang-treated group was higher than control group with significance on 14th day(P<0.05). 3. On the weight of solid tumor. Dangguihwalhyultang-treated group was less than control group with significance(P<0.05). 4. On the MTT assay. Dangguihwalhyultang concentration inhibited cell viability was $368.8{\mu}g/well$. 5. Natural killer cell activity in Dangguihwalhyultang-treated group was significantly increased on 100:1, 50:1 E/T(effect cell/target cell) ratio(P<0.05). 6. Production of interleukin-2 in Dangguihwalhyultang-treated group was significantly increased(P<0.05).

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