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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제25권 제5호
- 발행연도
- 2002.1
- 수록면
- 664 - 668 (5page)
이용수
초록· 키워드
오류제보하기
KR-31543,(2S,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amino]-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-1-benzopyran is a new neuroprotetive agent for ischemia-reperfusion damage. The in vitro and in vivo metabolism of KR-31543 in rats has been studied by LC-electrospray mass spectrometry. Rat liver microsomal incubation of KR-31543 in the presence of NADPH resulted in the formation of a metabolite M1. M1 was identified as N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine on the basis of LC-MS/MS analysis with the synthesized authentic standard. Rat CYP3A1 and 3A2 are the major CYP isozymes involved in the formation of M1.
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In Vitro Metabolism of a New Neuroprotective Agent, KR-31543 in the Human Liver Microsomes : Identification of Human Cytochrome P450
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Simultaneous Determination of the Novel Neuroprotective Agent KR-31378 and its Metabolite KR-31612 Using High Performance Liquid Chromatography with Tandem Mass Spectrometry in Human Plasma
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Effects of a New Neuroprotective Agent KR-31378 on Liver Cytochrome P450s in Male Sprague Dawley Rats
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High-Performance Liquid Chromatographic Analysis, Blood Partition and Protein ′binding of a New Neuroprotective Agent for Ischemia-reperfusion Damage, KR-31378
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Neuroprotective effect of KR-31378 in cortical cell culture and in brain ischemia-reperfusion model
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In vitro metabolism of a new protective agent, KR-31543 in human liver microsomes
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HPLC Analysis, Stability, B1ood Partition, Protein Binding, and Dose-independent Pharmacokinetics of KR-31543, a New Neuroprotective Agent for Ischemia-reperfusion Damage
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Effect of Trolox C on CYP450 Isozymes Activity and Expression in Hepatic Ischemia/Reperfusion
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Dose-Independent Pharmacokinetics of a New Neuroprotective Agent for Ischemia-Reperfusion Damage, KR-31543, after Intravenous and Oral Administration to Rats: Hepatic and Intestinal First-Pass Effects
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In Vitro Metabolism of a New Cardioprotective Agent, KR-33028 in the Human Liver Microsomes and Cryopreserved Human Hepatocytes
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Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line
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Effects of CYP1A2$^*$1C and CYP1A2$^*$1F Genotypes on the Activity and Inducibility of CYP1A2 Determined by Urinary Caffeine Metabolite Ratio in Koreans
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Kinetic Characterization of Brain Distribution for KR-31378 in Rats
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Simultaneous determination of seven major human cytochrome P450 activities using LC/MS/MS
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Antiarrhythmic Effects of KR-32570, a Novel Na-H Exchanger Inhibitor, on Ischemia/Reperfusion-Induced Arrhythmias
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