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논문 기본 정보

자료유형
학술저널
저자정보
Yoo, Young-Chan (National Institute of Scientific Investigation) Chung, Hee-Sun (National Institute of Scientific Investigation) Choi, Hwa-Kyung (National Institute of Scientific Investigation)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제16권 제3호
발행연도
1993.1
수록면
175 - 179 (5page)

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Gas chromoatography with flame ionization detector (FID) along with mass spectrometry (GC/MS) were used for the screening and quantification of methamphetamine (MA) and its major metabolite, amphetamine (AM0, in blood and urine in eleven fatal cases in which MA abuse was suspected. Postmortem blood MA varied from $0.5-30.2\;\mu{g/ml}$, while Am levels ranged from none detected (6 of 11 cases) to 4.8 .mu.g/ml. Additionally, distribution studies were performed in three of these cases in which tissue smaples were available for evaluation. Liver contained the highest ocncentration of MA among the tissu samples. In eight of the eleven cases, when no other direct cause of death was evident (i.e. 3 cases of traumatic dath0, either no blood AM was found or the ratio of MA/AM was 3.4 or greater. These data are consistent with acute MA use followed by death due to acute drug intoxication or by the occurrence of hypersensitivity and reverse seen in cases of chronic drug abuse.

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