Long-term chemical castration induces depressive symptoms by suppressing serotonin expression in rats

Han, Jin-Hee; Shin, Mal-Soon; Lee, Jae-Min; Kim, Tae-Woon; Jin, Jun-Jang; Ko, Il-Gyu; Kim, Sung-Eun; Kim, Chang-Ju; Kim, Mia; Rohe, Joo Hwan; Kim, Khae Hawn

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자료유형: 학술저널

저자정보: Han, Jin-Hee (Department of Anesthesiology and Pain Medicine, Kyung Hee Medical Center, Kyung Hee University College of Medicine) Shin, Mal-Soon (School of Global Sport Studies, Korea University) Lee, Jae-Min (Department of Physiology, College of Medicine, Kyung Hee University) Kim, Tae-Woon (Department of Physiology, College of Medicine, Kyung Hee University) Jin, Jun-Jang (Department of Physiology, College of Medicine, Kyung Hee University) Ko, Il-Gyu (Department of Physiology, College of Medicine, Kyung Hee University) Kim, Sung-Eun (Department of Physiology, College of Medicine, Kyung Hee University) Kim, Chang-Ju (Department of Physiology, College of Medicine, Kyung Hee University) Kim, Mia (Department of Cardiovascular and Neurologic Diseases [Stroke Center], College of Oriental Medicine, Kyung Hee University) Rohe, Joo Hwan (Department of Urology, Gil Medical Center, Gachon University College of Medicine and Science) Kim, Khae Hawn (Department of Urology, Gil Medical Center, Gachon University College of Medicine and Science)

저널정보: 한국통합생물학회 Animal cells and systems Animal cells and systems 제22권 제1호

발행연도: 2018.1

수록면: 29 - 36 (8page)

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Androgen deprivation therapy, also known as chemical castration, has been used as an adjunct to psychotherapy for sex offenders. Goserelin and bicalutamide are drugs used for chemical castration. Serotonin (5-hydroxytryptamine, 5-HT) is a key neurotransmitter involved in mood changes, such as depression. We investigated the effects of surgical and chemical castration on depressive symptoms in rats. Surgical castration was performed through a bilateral orchiectomy. Bicalutamide was administrated orally once a day for 84 consecutive days. Goserelin acetate was implanted subcutaneously into the anterior abdominal wall, and this implantation was repeated 3 times at 28-day intervals. Testosterone levels were detected by enzyme-linked immunosorbent assays. Sexual behaviors were analyzed by measuring mount latency, mount frequency, intromission latency, and intromission frequency. The forced swimming test was performed to evaluate rats' depression status. To detect 5-HT and tryptophan hydroxylase (TPH)-positive cells in the dorsal raphe, immunohistochemistry for 5-HT and TPH and western blotting for 5-HT1A receptors and TPH were performed. Surgical castration and goserelin decreased testosterone levels and suppressed sexual behaviors. However, bicalutamide did not inhibit sexual behaviors, although it reduced testosterone levels to a limited extent. Both surgical and chemical castration induced depression in rats. The expression of 5-HT, TPH, and 5-HT1A receptors in the dorsal raphe was significantly decreased by both surgical castration and chemical castration via bicalutamide and goserelin. The present results showed that surgical and chemical castration for 12 weeks induced a depressive state in rats by inhibiting serotonergic function through 5-HT1A receptors.

#Castration #sexual behaviors #testosterone #serotonin #depression

참고문헌 (37)

참고문헌 신청

Ahmadi-Davis S / 2014 / Goserelin-induced depression in a man with prostate cancer / Psychosomatics 55:720~722

Albert PR / 1996 / The 5-HT1A receptor: signaling, desensitization, and gene transcription / Neuropsychopharmacology 14:19~25

Bach-Mizrachi H / 2006 / Neuronal tryptophan hydroxylase mRNA expression in the human dorsal andmedian raphe nuclei: major depression and suicide / Neuropsychopharmacology 31:814~824

Barnes NM / 1999 / A review of central 5-HT receptors and their function / Neuropharmacology 38:1083~1152

Baumann B / 2002 / Circumscribed numerical deficit of dorsal raphe neurons in mood disorders / Psychol Med 32:93~103

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이 논문의 저자 정보

Han, Jin-Hee

소속기관 Department of Anesthesiology and Pain Medicine, Kyung Hee Medical Center, Kyung Hee University Colle

주요연구분야 자연과학 > 생물학

논문수 4 이용수 10

Shin, Mal-Soon

소속기관 School of Global Sport Studies, Korea University

주요연구분야 자연과학 > 생물학

논문수 3 이용수 7

Lee, Jae-Min