여성 우울증 입원 환자에서 폐경 여부에 따른 인지기능의 차이

유지영; 민정아; 전양환; 한상익; 박이진

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자료유형: 학술저널

저자정보: 유지영 (가톨릭대학교 의과대학 인천성모병원 정신과학교실) 민정아 (가톨릭대학교 의과대학 인천성모병원 정신과학교실) 전양환 (가톨릭대학교 의과대학 인천성모병원 정신과학교실) 한상익 (가톨릭대학교 의과대학 인천성모병원 정신과학교실) 박이진 (가톨릭대학교 의과대학 인천성모병원 정신과학교실)

저널정보: 대한생물정신의학회 생물정신의학 생물정신의학 제23권 제4호

발행연도: 2016.1

수록면: 199 - 204 (6page)

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Objectives Although forgetfulness is a common complaint among menopausal depressed women, there is still a debate about the relationship between memory impairment and menopause. The aim of this study is to examine whether menopause is related to cognitive decline among women with depressive disorders. We hypothesized that postmenopausal depressed women show generally poorer performance than premenopausal depressed women on various cognitive function tests. Methods With a retrospective chart review, we identified a total of 87 female patients (45 premenopausal patients and 42 postmenopausal patients) who were hospitalized with depressive disorders from 2000 to 2016. Demographic and clinical variables and cognitive test results were compared between two groups. Results Education year is longer in premenopausal group than postmenopausal group whereas clinical characteristics (illness duration, recurrence, and symptom severity) and mean Intelligence Quotient (IQ) were similar between two groups. The postmenopausal group took longer time for Bender-Gestalt Test (BGT) recall, Trail Making Test (TMT)-A, and TMT-B than the premenopausal group. After controlling for age and education, significant difference was remained for BGT recall (p = 0.029). Conclusions Postmenopausal state may be related with decline of visuospatial memory function, in particular, among depressed female patients. Other areas of cognitive function including complex attention, verbal memory, auditory memory, and working memory might be interpreted while considering age and education level.

#폐경 #인지기능 #우울증

참고문헌 (49)

참고문헌 신청

Ballard KD / 2001 / The role of the menopause in women’s experiences of the “change of life.” / Sociol Health Illn 23:397~424

Oppermann K / 2012 / Physical, psychological, and menopause-related symptoms and minor psychiatric disorders in a community-based sample of Brazilian premenopausal, perimenopausal, and postmenopausal women / Menopause 19:355~360

Gold EB / 2000 / Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40-55 years of age / Am J Epidemiol 152:463~473

Paganini-Hill A / 1994 / Estrogen deficiency and risk of Alzheimer's disease in women / Am J Epidemiol 140:256~261

Laws KR / 2016 / Sex differences in cognitive impairment in Alzheimer’s disease / World J Psychiatry 6:54~65

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