지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives Obsessive-compulsive disorder (OCD) is a chronic and disabling psychiatric disorder. The duration of untreated illness (DUI) has been suggested as one of the predictors of clinical course and outcome in various psychiatric disorders. There is increasing evidence that cognitive dysfunction is associated with the prognosis of OCD. The aim of this study was to investigate the influence of DUI on the neurocognitive functions in patients with OCD. Methods Sixty-two patients with a DSM-IV diagnosis of OCD from the outpatient clinic were included in this study. We defined the short DUI if the DUI was 2-year or less and the long DUI if it was longer than 2-year. Neurocognitive functions were assessed by visuospatial memory function test and 4 subsets of K-WAIS such as vocabulary, arithmetic, block design and picture arrangement. Differences in neurocognitive functions as well as clinical variables between OCD patients with short DUI and those with long DUI were investigated. Correlation analyses were also performed to determine the correlation between DUI and neurocognitive functions. Results Compared with the short DUI group, the long DUI group performed worse in the block design test, which measures executive function. The long DUI group also had a higher level of compulsive symptom severity than the short DUI group. However, the DUI was not correlated with neurocognitive functions. Conclusions Findings in this preliminary study suggest that the long DUI in patients with OCD is associated with more severe executive dysfunction. Studies with larger samples and longitudinal design are needed to further confirm the prognostic role of the DUI in OCD.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Ruscio AM / 2010 / The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication / Mol Psychiatry 15:53~63
Skoog G / 1999 / A 40-year follow-up of patients with obsessivecompulsive disorder [see commetns] / Arch Gen Psychiatry 56:121~127
Subramaniam M / 2013 / Quality of life in obsessive-compulsive disorder: impact of the disorder and of treatment / CNS Drugs 27:367~383
Fineberg NA / 2013 / Pharmacotherapy of obsessive-compulsive disorder: evidence-based treatment and beyond / Aust N Z J Psychiatry 47:121~141
Jakubovski E / 2013 / Clinical predictors of long-term outcome in obsessive-compulsive disorder / Depress Anxiety 30:763~772
Skoog G / 1999 / A 40-year follow-up of patients with obsessivecompulsive disorder [see commetns] / Arch Gen Psychiatry 56:121~127
Subramaniam M / 2013 / Quality of life in obsessive-compulsive disorder: impact of the disorder and of treatment / CNS Drugs 27:367~383
Fineberg NA / 2013 / Pharmacotherapy of obsessive-compulsive disorder: evidence-based treatment and beyond / Aust N Z J Psychiatry 47:121~141
Jakubovski E / 2013 / Clinical predictors of long-term outcome in obsessive-compulsive disorder / Depress Anxiety 30:763~772
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