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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 469 - 474 (6page)
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초록· 키워드
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Liriopogons (Liriope and Opiopogon) species are used as a main medicinal ingredient in several Asian countries. The Liriopes Radix (tuber, root of Liriope platyphylla) has to be a promising candidate due to their source of phytochemicals. Steroidal saponins and their glycosides, phenolic compounds, secondary metabolites are considered of active constituents in Liriopes Radix. Spicatoside A, a steroidal saponin, could be more efficacious drug candidate in future. In this review, we summarized the available knowledge on phytochemical and pharmacological activities for spicatoside A. It significantly suppressed the level of NF-${\kappa}B$, NO, iNOS, Cox-2, IL-$1{\beta}$, IL-6 and MAPKs in LPS-stimulated inflammation. The production of MUC5AC mucin was increased. MMP-13 expression was down-regulated in IL-$1{\beta}$-treated cells and reduced glycosaminoglycan release from IL-$1{\alpha}$-treated cells. The neurite outgrowth activity, PI3K, Akt, ERK1/2, TrkA and CREB phosphorylation and neurotropic factors such as NGF and BDNF were upregulated with increased latency time. It also showed cell growth inhibitory activity on various carcinoma cells. From this, spicatoside A exerts anti-inflammation, anti-asthma, anti-osteoclastogenesis, neurite outgrowth, memory consolidation and anticancer activities. Further studies are needed on spicatoside A in order to understand mechanisms of action to treat various human diseases.
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참고문헌 (32)
참고문헌 신청
Backer, R. C / 1972 / A phytochemical investigation of Yucca schottii (Liliaceae) / J. Pharm. Sci 61:1665~1666
Baek, N. -I / 1998 / Cytotoxicity of steroid-saponins from the tuber of Liriope platyphylla W. T. Agric / Chem. Biotechnol 41:390~394
Bai, C. -C / 2008 / Sensitive determination of saponins in radix et rhizoma notoginseng by charged aerosol detector coupled with HPLC. J. Liq / Chromatogr. Relat. Technol 32:242~260
Barres, B. A / 2000 / Neuronal and glial cell biology / Curr. Opin. Neurobiol 10:642~648
Bartoletti, A / 2002 / Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway-specific impairment of long-term potentiation but normal critical period for monocular deprivation / J. Neurosci 22:10072~10077
Baek, N. -I / 1998 / Cytotoxicity of steroid-saponins from the tuber of Liriope platyphylla W. T. Agric / Chem. Biotechnol 41:390~394
Bai, C. -C / 2008 / Sensitive determination of saponins in radix et rhizoma notoginseng by charged aerosol detector coupled with HPLC. J. Liq / Chromatogr. Relat. Technol 32:242~260
Barres, B. A / 2000 / Neuronal and glial cell biology / Curr. Opin. Neurobiol 10:642~648
Bartoletti, A / 2002 / Heterozygous knock-out mice for brain-derived neurotrophic factor show a pathway-specific impairment of long-term potentiation but normal critical period for monocular deprivation / J. Neurosci 22:10072~10077
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