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논문 기본 정보

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학술저널
저자정보
Yun, Jaesuk (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Gu, Sun Mi (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Lee, Tac-hyung (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Song, Yun Jeong (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Seong, Seonhwa (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Kim, Young-Hoon (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Cha, Hye Jin (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Han, Kyoung Moon (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Shin, Jisoon (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Oh, Hokyung (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Jung, Kikyung (National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) Ahn, Chiyoung (National I) Park, Hye-Kyung Kim, Hyung Soo
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제25권 제3호
발행연도
2017.1
수록면
266 - 271 (6page)

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Synthetic cannabinoids are one of most abused new psychoactive substances. The recreational use of abused drug has aroused serious concerns about the consequences of these drugs on infection. However, the effects of synthetic cannabinoid on resistance to tetanus toxin are not fully understood yet. In the present study, we aimed to determine if the administration of synthetic cannabinoids increase the susceptibility to tetanus toxin-induced motor behavioral deficit and functional changes in cerebellar neurons in mice. Furthermore, we measured T lymphocytes marker levels, such as CD8 and CD4 which against tetanus toxin. JWH-210 administration decreased expression levels of T cell activators including cluster of differentiation (CD) $3{\varepsilon}$, $CD3{\gamma}$, CD74p31, and CD74p41. In addition, we demonstrated that JWH-210 induced motor impairment and decrement of vesicle-associated membrane proteins 2 levels in the cerebellum of mice treated with tetanus toxin. Furthermore, cerebellar glutamatergic neuronal homeostasis was hampered by JWH-210 administration, as evidenced by increased glutamate concentration levels in the cerebellum. These results suggest that JWH-210 may increase the vulnerability to tetanus toxin via the regulation of immune function.
#New psychoactive substances #Cytokine #T cell activator #Tetanus toxin #Motor impairment #Glutamate

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참고문헌 (30)

참고문헌 신청
Berdyshev, E. V. / 2000 / Cannabinoid receptors and the regulation of immune response / Chem. Phys. Lipids 108:169~190 google schola Blum, F. C. / 2012 / Tetanus toxin and botulinum toxin a utilize unique mechanisms to enter neurons of the central nervous system / Infect. Immun 80:1662~1669 google schola Brazin, K. N. / 2014 / Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments / J. Biol. Chem 289:18880~18892 google schola Cutando, L. / 2013 / Microglial activation underlies cerebellar deficits produced by repeated cannabis exposure / J. Clin. Invest 123:2816~2831 google schola Fattore, L. / 2011 / Beyond THC: The new generation of cannabinoid designer drugs / Front. Behav. Neurosci 5:60 google schola

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