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논문 기본 정보

자료유형
학술저널
저자정보
Choi, Jong Hyun (Department of Internal Medicine, Korea University Guro Hospital) Choi, Juwhan (Department of Internal Medicine, Korea University Guro Hospital) Chung, Sang Mi (Department of Internal Medicine, Korea University Guro Hospital) Oh, Jee Youn (Department of Internal Medicine, Korea University Guro Hospital) Lee, Young Seok (Department of Internal Medicine, Korea University Guro Hospital) Min, Kyung Hoon (Department of Internal Medicine, Korea University Guro Hospital) Hur, Gyu Young (Department of Internal Medicine, Korea University Guro Hospital) Shim, Jae Jeong (Department of Internal Medicine, Korea University Guro Hospital) Kang, Kyung Ho (Department of Internal Medicine, Korea University Guro Hospital) Lee, Hyun Kyung (Department of Internal Medicine, Inje University Busan Paik Hospital) Lee, Sung Yong (Department of Internal Medicine, Korea University Guro Hospital)
저널정보
대한결핵 및 호흡기학회 Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제82권 제3호
발행연도
2019.1
수록면
211 - 216 (6page)

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Background: Docetaxel is one of the standard treatments for advanced non-small cell lung cancer. Docetaxel is usually administered in a 3-week schedule, but there is significant toxicity. In this phase II clinical study, we investigated the efficacy and safety of a 4-weekly schedule of docetaxel monotherapy, as first-line chemotherapy for advanced squamous cell carcinoma in elderly lung cancer patients. Methods: Patients with stage IIIB/ IV lung squamous-cell carcinoma age 70 or older, that had not undergone cytotoxic chemotherapy were enrolled. Patients received docetaxel $25mg/m^2$ on days 1, 8, and 15, every 4 weeks. Primary endpoint was the objective response rate (ORR). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity profiles. Results: A total of 19 patients were enrolled. Among 19 patients, 17 were for evaluated efficacy and safety. In the intent-to-treat population, ORR and disease control rate (DCR) were 11.8% and 47.1%, respectively. In the response evaluable population, ORR was 16.7% and DCR was 66.7%. Median PFS and OS were 3.1 months and 3.3 months, respectively. There were three adverse grade 3/4 events. Grade 1 neutropenia was reported in one patient. Conclusion: Our data failed to demonstrate efficacy of a 4-weekly docetaxel regimen, in elderly patients with a poor performance status. However, incidence of side effects, including neutropenia, was lower than with a 3-week docetaxel regimen, as previously reported.

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