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논문 기본 정보

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학술저널
저자정보
Lee Hyun Jung (Department of Internal Medicine Pusan National University College of Medicine Busan Korea) Kim Gwang Ha (Department of Internal Medicine Pusan National University College of Medicine Busan KoreaBiomedical) Park Su Jin (Department of Internal Medicine Pusan National University College of Medicine Busan KoreaBiomedical) Kwon Chae Hwa (Biomedical Research Institute Pusan National University Hospital Busan Korea) Lee Moon Won (Department of Internal Medicine Pusan National University College of Medicine Busan Korea) Lee Bong Eun (Department of Internal Medicine Pusan National University College of Medicine Busan Korea) Baek Dong Hoon (Department of Internal Medicine Pusan National University College of Medicine Busan Korea) I Hoseok (Department of Thoracic Surgery Pusan National University College of Medicine Busan Korea)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제4호
발행연도
2021.1
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553 - 561 (9page)

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Background/Aims: Unlike other gastrointestinal tract cancers, there are relatively few reports on the clinical significance of circulating tumor cells (CTCs) and TWIST, a marker of epithelial-mesenchymal transition, in patients with esophageal squamous cell carcinoma (ESCC). This study aimed to evaluate the clinical significance of TWIST expression in CTCs in patients with ESCC. Methods: Peripheral blood samples for CTC analyses were prospectively obtained from 52 patients with ESCC prior to treatment between September 2017 and September 2019. CTCs were detected using a centrifugal microfluidic system based on a fluid-assisted separation technique, and CTCs positive for TWIST on immunostaining were defined as TWIST (+) CTCs. Results: Of the 52 patients with ESCC, CTCs and TWIST (+) CTCs were detected in 44 patients (84.6%) and 39 patients (75.0%), respectively. The CTC and TWIST (+) CTC counts were significantly higher in patients aged >65 years and those who had a large tumor (>3 cm) than in those aged ≤65 years and those who had a small tumor (≤3 cm), respectively. There were no differences in CTC and TWIST (+) CTC counts according to tumor location, histologic grade, or TNM stage. TWIST (+) CTCs were significantly associated with histologic grade; a proportion of TWIST (+) CTCs ≥0.5 was significantly associated with advanced histologic grade. Other clinicopathologic characteristics such as sex, age, tumor location, tumor size, and TNM stages were not significantly associated with TWIST (+) CTCs. Conclusions: Our study showed that TWIST (+) CTCs were frequently detected in patients with ESCC, and a high proportion of TWIST (+) CTCs was associated with poor differentiation.
#Circulating tumor cells #Esophageal neoplasms #Squamous cell carcinoma #TWIST

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참고문헌 (32)

참고문헌 신청
Ferlay J / 2015 / Cancer incidence and mortality worldwide : sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359 google schola 정혜경 / 2019 / 식도암의 국내 현황 및 병인 / Korean Journal of Helicobacter Upper Gastrointestinal Research 19(3):145~148 Crossref Wu T / 2017 / Clinical applications of circulating tumor cells in pharmacotherapy : challenges and perspectives / Mol Pharmacol 92:232~239 google schola Qiao Y / 2017 / Prognostic value of circulating tumor cells in the peripheral blood of patients with esophageal squamous cell carcinoma / Onco Targets Ther 10:1363~1373 google schola Han L / 2019 / Clinical significance of tumor cells in the peripheral blood of patients with esophageal squamous cell carcinoma / Medicine(Baltimore) 98:e13921 google schola

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