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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 151 - 158 (8page)
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Circulating tumor cells (CTCs) are tumor cells that are separated from the primary site or metastatic lesion and disseminate in blood circulation. CTCs are considered to be part of the long process of cancer metastasis. As a ‘liquid biopsy’, CTC molecular examination and investigation of single cancer cells create an important opportunity for providing an understanding of cancer biology and the process of metastasis. In the last decade, we have seen dramatic development in defining the role of CTCs in lung cancer in terms of diagnosis, genomic alteration determination, treatment response and, finally, prognosis prediction. The aims of this review are to understand the basic biology and to review methods of detection of CTCs that apply to the various types of solid tumor. Furthermore, we explored clinical applications, including treatment monitoring to anticipate therapy resistance as well as biomarker analysis, in the context of lung cancer. We also explored the potential use of cell-free circulating tumor DNA (ctDNA) in the genomic alteration analysis of lung cancer.
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참고문헌 (114)
참고문헌 신청
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Siegel RL / 2015 / Cancer statistics, 2015 / CA Cancer J Clin 65:5~29
Kanodra NM / 2015 / Screening and early detection efforts in lung cancer / Cancer 121:1347~1356
Infante M / 2015 / Long-term follow-up results of the DANTE trial, a randomized study of lung cancer screening with spiral computed tomography / Am J Respir Crit Care Med 191:1166~1175
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Siegel RL / 2015 / Cancer statistics, 2015 / CA Cancer J Clin 65:5~29
Kanodra NM / 2015 / Screening and early detection efforts in lung cancer / Cancer 121:1347~1356
Infante M / 2015 / Long-term follow-up results of the DANTE trial, a randomized study of lung cancer screening with spiral computed tomography / Am J Respir Crit Care Med 191:1166~1175
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