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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 185 - 193 (9page)
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Histone deacetylation and demethylation are epigenetic mechanisms implicated in cancer. Studies regarding the role of modulation of gene expression utilizing the histone deacetylase inhibitor scriptaid and the demethylating agent 5-azacytidine in HL-60 leukemia cells have been limited. We studied the possibility of recovering epigenetically silenced genes by scriptaid and 5-azacytidine in human leukemia cells by DNA microarray analysis. The first group was leukemia cells that were cultured with 5-azacytidine. The second group was cultured with scriptaid. The other group was cultured with both agents. Two hundred seventy newly developed genes were expressed after the combination of 5-azacytidine and scriptaid. Twenty-nine genes were unchanged after the combination treatment of 5-azacytidine and scriptaid. Among the 270 genes, 13 genes were differed significantly from the control. HPGD, CPA3, CEACAM6, LOC653907, ETS1, RAB37, PMP22, FST, FOXC1, and CCL2 were up-regulated, and IGLL3, IGLL1, and ASS1 were down-regulated. Eleven genes associated with oncogenesis were found among the differentially expressed genes: ETS1, ASCL2, BTG2, BTG1, SLAMF6, CDKN2D, RRAS, RET, GIPC1, MAGEB, and RGL4. We report the results of our leukemia cell microarray profiles after epigenetic combination therapy with the hope that they are the starting point of selectively targeted epigenetic therapy.
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참고문헌 (36)
참고문헌 신청
Bali, P. / 2005 / Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90 / J. Biol. Chem. 280:26729
Benabdallah, B. / 2009 / Overexpression of follistatin in human myoblasts increases their proliferation and differentiation, and improves the graft success in SCID mice / Cell Transplantation 18:709~718
Bishton, M. / 2007 / Epigenetic targets in hematological malignancies: combination therapies with HDACis and demethylating agents / Expert Review of Anticancer Therapy 7:1439~1449
Bossers, K. / 2010 / Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease / Brain 133:3699~3723
Cameron, E. / 1999 / Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer / Nature Genet. 21:103~107
Benabdallah, B. / 2009 / Overexpression of follistatin in human myoblasts increases their proliferation and differentiation, and improves the graft success in SCID mice / Cell Transplantation 18:709~718
Bishton, M. / 2007 / Epigenetic targets in hematological malignancies: combination therapies with HDACis and demethylating agents / Expert Review of Anticancer Therapy 7:1439~1449
Bossers, K. / 2010 / Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease / Brain 133:3699~3723
Cameron, E. / 1999 / Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer / Nature Genet. 21:103~107
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