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논문 기본 정보
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- 학술저널
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- 2017.1
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Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the various processes occurring at different levels, gene expression regulation is especially crucial for proper memory processing, as some genes need to be activated while some genes must be suppressed. Epigenetic regulation of the genome involves processes such as DNA methylation and histone post-translational modifications. These processes edit genomic properties or the interactions between the genome and histone cores. They then induce structural changes in the chromatin and lead to transcriptional changes of different genes. Recent studies have focused on the concept of chromatin remodeling, which consists of 3D structural changes in chromatin in relation to gene regulation, and is an important process in learning and memory. In this review, we will introduce three major epigenetic processes involved in memory regulation: DNA methylation, histone methylation and histone acetylation. We will also discuss general mechanisms of long-term memory storage and relate the epigenetic control of learning and memory to chromatin remodeling. Finally, we will discuss how epigenetic mechanisms can contribute to the pathologies of neurological disorders and cause memory-related symptoms.
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참고문헌 (29)
참고문헌 신청
Bliss TV / 1973 / Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path / J Physiol
Borrelli E / 2008 / Decoding the epigenetic language of neuronal plasticity / Neuron 60 : 961 ~ 974
Day JJ / 2010 / DNA methylation and memory formation / Nat Neurosci 13 : 1319 ~ 1323
Dudai Y. / 2004 / The neurobiology of consolidations, or, how stable is the engram? / Annu Rev Psychol 55 : 51 ~ 86
Fischer A / 2007 / Recovery of learning and memory is associated with chromatin remodelling / Nature 447 : 178 ~ 182
Borrelli E / 2008 / Decoding the epigenetic language of neuronal plasticity / Neuron 60 : 961 ~ 974
Day JJ / 2010 / DNA methylation and memory formation / Nat Neurosci 13 : 1319 ~ 1323
Dudai Y. / 2004 / The neurobiology of consolidations, or, how stable is the engram? / Annu Rev Psychol 55 : 51 ~ 86
Fischer A / 2007 / Recovery of learning and memory is associated with chromatin remodelling / Nature 447 : 178 ~ 182
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