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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 685 - 690 (6page)
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The eukaryotic genome is packed into chromatin, which is important for the genomic integrity and gene regulation.
Chromatin structures are maintained through assembly and disassembly of nucleosomes catalyzed by histone chaperones.
Asf1 (anti-silencing function 1) is a highly conserved histone chaperone that mediates histone transfer on/off DNA and promotes histone H3 lysine 56 acetylation at globular core domain of histone H3. To elucidate the role of Asf1 in the modulation of chromatin structure, we screened and identified small molecules that inhibit Asf1 and H3K56 acetylation without affecting other histone modifications. These pyrimidine- 2,4,6-trione derivative molecules inhibited the nucleosome assembly mediated by Asf1 in vitro, and reduced the H3K56 acetylation in HeLa cells. Furthermore, production of HSV viral particles was reduced by these compounds. As Asf1 is implicated in genome integrity, cell proliferation, and cancer, current Asf1 inhibitor molecules may offer an opportunity for the therapeutic development for treatment of diseases.
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참고문헌 (25)
참고문헌 신청
Agez M / 2007 / Structure of the histone chaperone ASF1 bound to the histone H3 C-terminal helix and functional insights / Structure 15 : 191 ~ 199
Battu A / 2011 / ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation / Nucleic Acids Res 39 : 7931 ~ 7945
Das C / 2009 / CBP/p300-mediated acetylation of histone H3 on lysine 56 / Nature 459 : 113 ~ 117
Driscoll R / 2007 / Yeast Rtt109promotes genome stability by acetylating histone H3 on lysine 56 / Science 315 : 649 ~ 652
English CM / 2006 / Structural basis for the histone chaperone activity of Asf1 / Cell 127 : 495 ~ 508
Battu A / 2011 / ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation / Nucleic Acids Res 39 : 7931 ~ 7945
Das C / 2009 / CBP/p300-mediated acetylation of histone H3 on lysine 56 / Nature 459 : 113 ~ 117
Driscoll R / 2007 / Yeast Rtt109promotes genome stability by acetylating histone H3 on lysine 56 / Science 315 : 649 ~ 652
English CM / 2006 / Structural basis for the histone chaperone activity of Asf1 / Cell 127 : 495 ~ 508
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