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논문 기본 정보

자료유형
학술저널
저자정보
Hwang, In Wook (Department of Biological Sciences, College of Natural Science, Dankook University) Kim, Kicheol (Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco) Choi, Eun Ji (Department of Biological Sciences, College of Natural Science, Dankook University) Jin, Han Jun (Department of Biological Sciences, College of Natural Science, Dankook University)
저널정보
한국유전체학회 Genomics & informatics Genomics & informatics 제17권 제1호
발행연도
2019.1
수록면
111 - 117 (7page)

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Athletic performance is a complex multifactorial trait involving genetic and environmental factors. The heritability of an athlete status was reported to be about 70% in a twin study, and at least 155 genetic markers are known to be related with athlete status. Mitochondrial DNA (mtDNA) encodes essential proteins for oxidative phosphorylation, which is related to aerobic capacity. Thus, mtDNA is a candidate marker for determining physical performance. Recent studies have suggested that polymorphisms of mtDNA are associated with athlete status and/or physical performance in various populations. Therefore, we analyzed mtDNA haplogroups to assess their association with the physical performance of Korean population. The 20 mtDNA haplogroups were determined using the SNaPshot assay. Our result showed a significant association of the haplogroup F with athlete status (odds ratio, 3.04; 95% confidence interval, 1.094 to 8.464; p = 0.012). Athletes with haplogroup F ($60.64{\pm}3.04$) also demonstrated a higher Sargent jump than athletes with other haplogroups ($54.28{\pm}1.23$) (p = 0.041). Thus, our data imply that haplogroup F may play a crucial role in the physical performance of Korean athletes. Functional studies with larger sample sizes are necessary to further substantiate these findings.

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