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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Hyun-Jae (Department of Pharmacology, School of Medicine, Chungnam National University) Lee, Su-Yel (Department of Pharmacology, School of Medicine, Chungnam National University) Jeon, Byeong-Kyou (Department of Radiologic Technology, Daegu Health College) Lee, Jae-Woo (LG Life Science) Kim, Young-Sik (Department of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) Lee, Mi-Nam (Department of Pharmacology, School of Medicine, Chungnam National University) Lee, Choong-Jae (Department of Pharmacology, School of Medicine, Chungnam National University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제18권 제3호
발행연도
2010.1
수록면
294 - 299 (6page)

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In this study, we tried to investigate whether platycodin D significantly affects MUC5AC mucin production and gene expression induced by epidermal growth factor (EGF), phorbol ester (PMA) and tumor necrosis factor-$\alpha$ (TNF-$\alpha$) from human airway epithelial cells. Confluent NCI-H292 cells were pretreated with varying concentrations of platycodin D for 30 min and then stimulated with EGF, PMA and TNF-$\alpha$ for 24h, respectively. MUC5AC mucin gene expression and mucin protein production were measured by RT-PCR and ELISA. The results were as follows: (1) Platycodin D was found to inhibit the production of MUC5AC mucin protein induced by EGF, PMA, and TNF-$\alpha$, respectively. (2) It also inhibited the expression of MUC5AC mucin gene induced by the same inducers. These results suggest that platycodin D can regulate mucin gene expression and production of mucin protein, by directly acting on human airway epithelial cells.

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