지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 373 - 380 (8page)
이용수
초록· 키워드
오류제보하기
Sphingosine kinase 1 and its product, sphingosine 1-phosphate (S1P), as well as their receptors, have been implicated in inflammatory responses. The functions of receptors $S1P_1$ and $S1P_2$ on cell motility have been investigated. However, the function of $S1P_3$ has been poorly investigated. In this study, the roles of $S1P_3$ on inflammatory response were investigated in primary peritoneal macrophages. $S1P_3$ receptor was induced along with sphingosine kinase 1 by stimulation of lipopolysaccharide (LPS). LPS treatment induced inflammatory genes, such iNOS, COX-2, $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$. TY52156, an antagonist of $S1P_3$ suppressed the induction of inflammatory genes in a concentration dependent manner. Suppression of iNOS and COX-2 induction was further confirmed by western blotting and NO measurement. Suppression of $IL-1{\beta}$ induction was also confirmed by western blotting and ELISA. Caspase 1, which is responsible for $IL-1{\beta}$ production, was similarly induced by LPS and suppressed by TY52156. Therefore, we have shown $S1P_3$ induction in the inflammatory conditions and its pro-inflammatory roles. Targeting $S1P_3$ might be a strategy for regulating inflammatory diseases.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Differential Activation of Macrophages Based on Their Environment in Advanced Age
전남의대학술지
2020 .01
-
Regulation of Macrophage Activation and Differentiation in Atherosclerosis
지질·동맥경화학회지
2021 .09
-
The role of macrophages in gut inflammation
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Application of ex-vivo generated macrophages as potential cell therapy
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Melatonin significantly down-regulates long non-coding RNA Cox2 in M1 macrophages stimulated with LPS
한국실험동물학회 학술발표대회 논문집
2022 .07
-
SCAP deficiency in macrophages exacerbates inflammation by promoting M1 macrophage polarization
한국실험동물학회 학술발표대회 논문집
2020 .02
-
KLF10 as a regulator of macrophage activation and inflammation
한국실험동물학회 학술발표대회 논문집
2025 .02
-
The regulatory function of Hes1 in metabolic disease related macrophage
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Triglyceride Regulates the Expression of M1 and M2 Macrophage-specific Markers in THP-1 Monocytes
대한의생명과학회지
2016 .12
-
Comprehensive Lipid Profiling Recapitulates Enhanced Lipolysis and Fatty Acid Metabolism in Intimal Foamy Macrophages From Murine Atherosclerotic Aorta
Immune Network
2023 .08
-
Role of Osteal Macrophages in Bone Metabolism
Journal of Pathology and Translational Medicine
2015 .01
-
Cyclophilin A protects preterm birth by modulating macrophage polarization in a mouse model of inflammation-induced preterm birth
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Polarization of M2 Macrophages by Interaction between Prostate Cancer Cells Treated with Trichomonas vaginalis and Adipocytes
Parasites, Hosts and Diseases
2020 .06
-
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages
Immune Network
2021 .04
-
TNF promotes SREBP activity to regulate macrophage polarization and tissue repair
한국실험동물학회 학술발표대회 논문집
2019 .07
-
SREBP-1-induced lipid synthesis is required for macrophage function
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Select Macrophage Noncoding RNAs of Interest in Cardiovascular Disease
지질·동맥경화학회지
2020 .01
-
Viperin Deficiency Promotes Polarization of Macrophages and Secretion of M1 and M2 Cytokines
Immune Network
2018 .08
-
Macrophages in xenotransplantation
Clinical Transplantation and Research
2019 .01
-
New Insights Into Tissue Macrophages : From Their Origin to the Development of Memory
Immune Network
2015 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0