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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 177 - 185 (9page)
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Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of annexin A5 expression in PC-3 cells. To understand the role of annexin A5 in auranofin-mediated apoptosis, we performed microarray data analysis to study annexin A5-controlled gene expression in annexin A5 knockdown PC-3 cells. Of differentially expressed genes, plasminogen activator inhibitor (PAI)-2 was increased by annexin A5 siRNA confirmed by qRT-PCR and western blot. Treatment with auranofin decreased PAI-2 and increased annexin A5 expression as well as promoting apoptosis. Furthermore, auranofin-induced apoptosis was recovered by annexin A5 siRNA but it was promoted by PAI-2 siRNA. Interestingly, knockdown of annexin A5 rescued PAI-2 expression suppressed by auranofin. Taken together, our study suggests that induction of annexin A5 by auranofin may enhance apoptosis through suppression of PAI-2 expression in PC-3 cells.
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참고문헌 (39)
참고문헌 신청
Boersma, H. H. / 2005 / Past, present, and future of annexin A5: from protein discovery to clinical applications / J. Nucl. Med 46:2035~2050
Bohn, H. / 1979 / Isolation and characterization of a new placenta specific protein (PP10) (author’s transl) / Arch. Gynecol 227:125~134
Bolstad, B. M. / 2003 / A comparison of normalization methods for high density oligonucleotide array data based on variance and bias / Bioinformatics 19:185~193
Cardó-Vila, M. / 2003 / ανβ5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V / Mol. Cell 11:1151~1162
Phase I and II study of auranofin in chronic lymphocytic leukemia (CLL) / Clinicaltrials.gov
Bohn, H. / 1979 / Isolation and characterization of a new placenta specific protein (PP10) (author’s transl) / Arch. Gynecol 227:125~134
Bolstad, B. M. / 2003 / A comparison of normalization methods for high density oligonucleotide array data based on variance and bias / Bioinformatics 19:185~193
Cardó-Vila, M. / 2003 / ανβ5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V / Mol. Cell 11:1151~1162
Phase I and II study of auranofin in chronic lymphocytic leukemia (CLL) / Clinicaltrials.gov
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