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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 391 - 399 (9page)
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초록· 키워드
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As a major component of the epidermal tissue, a primary keratinocyte has served as an essential tool not only for the study of pathogenesis of skin-related diseases but also for the assessment of potential toxicities of various chemicals used in cosmetics. However, its short lifespan in ex vivo setting has been a great hurdle for many practical applications. Therefore, a number of immortalization attempts have been made with success to overcome this limitation. In order to understand the immortalization process of a primary keratinocyte, several key biological phenomena governing its lifespan will be reviewed first. Then, various immortalization methods for the establishment of stable keratinocyte cell lines will be explained. Finally, its application to a three-dimensional skin culture system will be described.
목차
등록된 정보가 없습니다.
참고문헌 (78)
참고문헌 신청
Allen-Hoffmann, B. L. / 2000 / Normal growth and differentiation in a spontaneously immortalized near-diploid human keratinocyte cell line, NIKS / J. Invest. Dermatol 114:444~455
Baden, H. P. / 1987 / Isolation and characterization of a spontaneously arising long-lived line of human keratinocytes (NM 1) / In Vitro Cell. Dev. Biol 23:205~213
Beausejour, C. M. / 2003 / Reversal of human cellular senescence:roles of the p53 and p16 pathways / EMBO J 22:4212~4222
Ben-Porath, I. / 2004 / When cells get stressed: an integrative view of cellular senescence / J. Clin. Invest 113:8~13
Ben-Porath, I. / 2005 / The signals and pathways activating cellular senescence / Int. J. Biochem. Cell Biol 37:961~976
Baden, H. P. / 1987 / Isolation and characterization of a spontaneously arising long-lived line of human keratinocytes (NM 1) / In Vitro Cell. Dev. Biol 23:205~213
Beausejour, C. M. / 2003 / Reversal of human cellular senescence:roles of the p53 and p16 pathways / EMBO J 22:4212~4222
Ben-Porath, I. / 2004 / When cells get stressed: an integrative view of cellular senescence / J. Clin. Invest 113:8~13
Ben-Porath, I. / 2005 / The signals and pathways activating cellular senescence / Int. J. Biochem. Cell Biol 37:961~976
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