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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 290 - 297 (8page)
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We aimed to understand the molecular changes in host cells that accompany infection by the seasonal influenza A H1N1 virus because the initial response rapidly changes owing to the fact that the virus has a robust initial propagation phase. Human epithelial alveolar A549 cells were infected and total RNA was extracted at 30 min, 1 h, 2 h, 4 h, 8 h, 24 h, and 48 h post infection (h.p.i.). The differentially expressed host genes were clustered into two distinct sets of genes as the infection progressed over time. The patterns of expression were significantly different at the early stages of infection. One of the responses showed roles similar to those associated with the enrichment gene sets to known 'gp120 pathway in HIV.' This gene set contains genes known to play roles in preventing the progress of apoptosis, which infected cells undergo as a response to viral infection. The other gene set showed enrichment of 'Drug Metabolism Enzymes (DMEs).' The identification of two distinct gene sets indicates that the virus regulates the cell's mechanisms to create a favorable environment for its stable replication and protection of gene metabolites within 8 h.
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참고문헌 (44)
참고문헌 신청
Alsuwaidi, A. R. / 2013 / Cellular bioenergetics, caspase activity and glutathione in murine lungs infected with influenza A virus / Virology 446:180~188
Bagga, S. / 2014 / Cell cycle regulation during viral infection / Methods Mol. Biol. 1170:165~227
Brown, S. G. / 2015 / Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis / Prostate 75:266~279
Chen, J. / 2012 / Adjuvant effect of docetaxel on the immune responses to influenza A H1N1 vaccine in mice / BMC Immunol. 13:36
Chen, W. / 2001 / A novel influenza A virus mitochondrial protein that induces cell death / Nat. Med. 7:1306~1312
Bagga, S. / 2014 / Cell cycle regulation during viral infection / Methods Mol. Biol. 1170:165~227
Brown, S. G. / 2015 / Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis / Prostate 75:266~279
Chen, J. / 2012 / Adjuvant effect of docetaxel on the immune responses to influenza A H1N1 vaccine in mice / BMC Immunol. 13:36
Chen, W. / 2001 / A novel influenza A virus mitochondrial protein that induces cell death / Nat. Med. 7:1306~1312
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