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자료유형
학술저널
저자정보
Feng, Xia (Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education) Zhang, Jing (Department of Environmental and Quality Inspection, Chongqing Chemical Industry Vocational College) Qian, Yu (Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education) Yi, Ruokun (Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education) Sun, Peng (Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education) Mu, Jianfei (Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education) Zhao, Xin (Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education) Song, Jia-Le (Department of Nutrition and Food Hygiene, School of Public Health, Guilin Medical University)
저널정보
한국응용생명화학회 Applied Biological Chemistry Applied Biological Chemistry 제61권 제3호
발행연도
2018.1
수록면
355 - 363 (9page)

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In this study, the preventative effects of Lactobacillus plantarum YS-3 (LP-YS3) on colitis were studied using an in vitro animal experiment. Oxazolone was administered to BALB/c mice to induce colitis, and the preventive effects of LP-YS3 were determined using serum- and tissue-related indexes. The mice treated with LP-YS3 showed a significant decrease (p<0.05) in disease activity index for colitis by inhibiting colon shortening and increasing colon weight/length ratio. The application of LP-YS3 resulted in a significant reduction in myeloperoxidase, nitric oxide, and malondialdehyde activities and a decrease in glutathione activity (p<0.05) in mouse colon tissues. LP-YS3 also significantly increased serum interleukin-2 and reduced interleukin-10 cytokines levels in mice (p<0.05). Reverse transcription-polymerase chain reaction and western blot assays showed that LP-YS3 application resulted in a significant increase in neuronal nitric oxide synthase, endothelial nitric oxide synthase, c-Kit, and stem cell factor expressions and a decrease in inducible nitric oxide synthase, interleukin-8, and C-X-C motif chemokine receptor 2 expressions in mouse colonic tissues (p<0.05). These findings indicate that LP-YS3 imparts preventative effects on oxazolone-induced colitis in mice.

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