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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

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학술저널
저자정보
Sohn, Seil (Department of Neurosurgery, Seoul National University College of Medicine) Chung, Chun Kee (Department of Neurosurgery, Seoul National University College of Medicine) Sohn, Moon Jun (Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University) Kim, Sung Hwan (Department of Radiation Oncology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) Kim, Jinhee (Department of Nursing, College of Medicine, Chosun University) Park, Eunjung (National Evidence-based Healthcare Collaborating Agency)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제59권 제1호
발행연도
2016.1
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37 - 43 (7page)

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Objective : The aim of this multicenter, matched-pair study was to compare the outcomes of stereotactic radiosurgery (SRS) and conventional external radiation therapy (RT) when used as a primary treatment in spine metastasis from hepatocellular carcinoma (HCC). Methods : From 2005 to 2012, 28 patients underwent SRS as the primary treatment in spine metastasis from HCC. Based on sex, age, number of spine metastasis, Child-Pugh classification, interval from original tumor to spine metastasis, and year of treatment, 28 patients who underwent RT were paired. Outcomes of interest were pain relief, progression free survival, toxicities, and further treatment. Results : The perioperative visual analog scale (VAS) decrease was larger in SRS group than in RT group, but the difference was not significant (3.7 vs. 2.8, p=0.13). When pain medication was adjusted, the number of patients with complete (n=6 vs.3) or partial (n=12 vs.13) relief was larger in SRS group than in RT group; however, the difference was not significant (p=0.83). There was no significant difference in progression free survival (p=0.48). In SRS group, 32.1% of patients had 1 or more toxicities whereas the percentage in RT group was 63.0%, a significant difference (p=0.04). Six SRS patients and 7 RT patients received further intervention at the treated segment. Conclusion : Clinical and radiological outcome were not significantly different between the two treatments. Toxicities, however, were more prevalent in the RT group.
#Radiosurgery #Radiation therapy #Spine #Metastasis #Hepatocellular carcinoma

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참고문헌 (28)

참고문헌 신청
Balagamwala EH / 2012 / Single-fraction stereotactic body radiotherapy for spinal metastases from renal cell carcinoma / J Neurosurg Spine 17:556~564 google schola Chang EL / 2007 / Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure / J Neurosurg Spine 7:151~160 google schola Chang UK / 2012 / Local tumor control after retreatment of spinal metastasis using stereotactic body radiotherapy; comparison with initial treatment group / Acta Oncol 51:589~595 google schola Chang UK / 2014 / Clinical result of stereotactic radiosurgery for spinal metastasis from hepatocellular carcinoma : comparison with conventional radiation therapy / J Neurooncol 119:141~148 google schola Cox JD / 1995 / Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) / Int J Radiat Oncol Biol Phys 31:1341~1346 google schola

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