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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 402 - 406 (5page)
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초록· 키워드
오류제보하기
In contrast to many of the malignant tumors that occur in the central nervous system in adults, the management, responses to therapy, and future perspectives of children with malignant lesions of the brain hold considerable promise. Within the past 5 years, remarkable progress has been made with our understanding of the basic biology of the molecular genetics of several pediatric malignant brain tumors including medulloblastoma, ependymoma, atypical teratoid rhabdoid tumour, and high grade glioma/diffuse intrinsic pontine glioma. The recent literature in pediatric neuro-oncology was reviewed, and a summary of the major findings are presented. Meaningful sub-classifications of these tumors have arisen, placing children into discrete categories of disease with requirements for targeted therapy. While the mainstay of therapy these past 30 years has been a combination of central nervous system irradiation and conventional chemotherapy, now with the advent of high resolution genetic mapping, targeted therapies have emerged, and less emphasis is being placed on craniospinal irradiation. In this article, the present and future perspective of pediatric brain malignancy are reviewed in detail. The progress that has been made offers significant hope for the future for patients with these tumours.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Alli S / 2018 / Brainstem blood brain barrier disruption using focused ultrasound / J Control Release
Biegel JA / 1999 / Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors / Cancer Res 59:74~79
Biggs PU / 1987 / Malignant rhabdoid tumor of the central nervous system / Hum Pathol 18:332~337
Cavalli FMG / 2017 / Intertumoral heterogeneity within medulloblastoma subgroups / Cancer Cell 31:737~754
Gajjar A / 2006 / Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial / Lancet Oncol 7:813~820
Biegel JA / 1999 / Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors / Cancer Res 59:74~79
Biggs PU / 1987 / Malignant rhabdoid tumor of the central nervous system / Hum Pathol 18:332~337
Cavalli FMG / 2017 / Intertumoral heterogeneity within medulloblastoma subgroups / Cancer Cell 31:737~754
Gajjar A / 2006 / Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial / Lancet Oncol 7:813~820
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